Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Jeong Shim; Christian Bo Poulsen; Mette K. Hagensen; Torben Larsen; Peter M.H. Heegaard; Christina Christoffersen; Lars Bolund; Mette Schmidt; Ying Liu; Juan Li; Rong Li; Henrik Callesen; Jacob F. Bentzon; Charlotte B. Sørensen

doi:10.1016/j.jacbts.2017.06.004

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Jeong Shim, Christian Bo Poulsen, Mette K. Hagensen, Torben Larsen, Peter M.H. Heegaard, Christina Christoffersen, Lars Bolund, Mette Schmidt, Ying Liu, Juan Li, Rong Li, Henrik Callesen, Jacob F. Bentzon^*, Charlotte B. Sørensen

^*Corresponding author af dette arbejde

6 Citationer (Scopus)

49 Downloads (Pure)

Abstract

Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE^−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE^−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

Originalsprog	Engelsk
Tidsskrift	JACC: Basic to Translational Science
Vol/bind	2
Udgave nummer	5
Sider (fra-til)	591-600
Antal sider	10
ISSN	2452-302X
DOI	https://doi.org/10.1016/j.jacbts.2017.06.004
Status	Udgivet - 2017

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10.1016/j.jacbts.2017.06.004Licens: CC BY-NC-ND

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified MinipigsForlagets udgivne version, 1,7 MBLicens: CC BY-NC-ND

Citationsformater

Shim, J., Poulsen, C. B., Hagensen, M. K., Larsen, T., Heegaard, P. M. H., Christoffersen, C., Bolund, L., Schmidt, M., Liu, Y., Li, J., Li, R., Callesen, H., Bentzon, J. F., & Sørensen, C. B. (2017). Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. JACC: Basic to Translational Science, 2(5), 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs. / Shim, Jeong; Poulsen, Christian Bo; Hagensen, Mette K. et al.
I: JACC: Basic to Translational Science, Bind 2, Nr. 5, 2017, s. 591-600.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Shim, J, Poulsen, CB, Hagensen, MK, Larsen, T, Heegaard, PMH, Christoffersen, C, Bolund, L, Schmidt, M, Liu, Y, Li, J, Li, R, Callesen, H, Bentzon, JF & Sørensen, CB 2017, 'Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs', JACC: Basic to Translational Science, bind 2, nr. 5, s. 591-600. https://doi.org/10.1016/j.jacbts.2017.06.004

@article{9070941818fb4095a4384df8d102d6b5,

title = "Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs",

abstract = "Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.",

keywords = "apolipoprotein E, atherosclerosis, pig, remnant cholesterol dysbetalipoproteinemia",

author = "Jeong Shim and Poulsen, {Christian Bo} and Hagensen, {Mette K.} and Torben Larsen and Heegaard, {Peter M.H.} and Christina Christoffersen and Lars Bolund and Mette Schmidt and Ying Liu and Juan Li and Rong Li and Henrik Callesen and Bentzon, {Jacob F.} and S{\o}rensen, {Charlotte B.}",

year = "2017",

doi = "10.1016/j.jacbts.2017.06.004",

language = "English",

volume = "2",

pages = "591--600",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

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number = "5",

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TY - JOUR

T1 - Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

AU - Shim, Jeong

AU - Poulsen, Christian Bo

AU - Hagensen, Mette K.

AU - Larsen, Torben

AU - Heegaard, Peter M.H.

AU - Christoffersen, Christina

AU - Bolund, Lars

AU - Schmidt, Mette

AU - Liu, Ying

AU - Li, Juan

AU - Li, Rong

AU - Callesen, Henrik

AU - Bentzon, Jacob F.

AU - Sørensen, Charlotte B.

PY - 2017

Y1 - 2017

N2 - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

AB - Deficiency of apolipoprotein E (APOE) causes familial dysbetalipoproteinemia in humans resulting in a higher risk of atherosclerotic disease. In mice, APOE deficiency results in a severe atherosclerosis phenotype, but it is unknown to what extent this is unique to mice. In this study, APOE was targeted in Yucatan minipigs. APOE−/− minipigs displayed increased plasma cholesterol and accumulation of apolipoprotein B-48–containing chylomicron remnants on low-fat diet, which was significantly accentuated upon feeding a high-fat, high-cholesterol diet. APOE−/− minipigs displayed accelerated progressive atherosclerosis but not xanthoma formation. This indicates that remnant lipoproteinemia does not induce early lesions but is atherogenic in pre-existing atherosclerosis.

KW - apolipoprotein E

KW - atherosclerosis

KW - pig

KW - remnant cholesterol dysbetalipoproteinemia

U2 - 10.1016/j.jacbts.2017.06.004

DO - 10.1016/j.jacbts.2017.06.004

M3 - Journal article

C2 - 30062172

AN - SCOPUS:85042148702

SN - 2452-302X

VL - 2

SP - 591

EP - 600

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 5

ER -

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Abstract

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