Aortic augmentation index: reference values in a large unselected population by means of the SphygmoCor device

TY - JOUR

T1 - Aortic augmentation index: reference values in a large unselected population by means of the SphygmoCor device

AU - Janner, Julie Hjortsø

AU - Godtfredsen, Nina S

AU - Ladelund, Steen

AU - Vestbo, Jørgen

AU - Prescott, Eva

AU - Janner, Julie

PY - 2010/2/1

Y1 - 2010/2/1

N2 - BackgroundArterial stiffness and pulse wave reflection are associated with cardiovascular disease (CVD). Pulse wave analyses (PWAs) allow the estimation of the central augmentation index (AIx), a measurement of pulse wave reflection. To understand the predictive role of AIx, reference values for AIx are needed.MethodsThis population study is based on 4,561 subjects from The Copenhagen City Heart Study, an ongoing epidemiological survey started in 1976, including subjects randomly chosen from the population in Copenhagen, Denmark. We calculated and internally validated reference values of AIx measured by the SphygmoCor device in a cohort without known CVD or diabetes, and with low risk of CVD according to HeartScore using gender-specific multiple regression analyses adjusting for age, heart rate, and height.ResultsAIx was significantly higher in women than in men, 30% vs. 22%, (P<0.001) and the increase in AIx with age was curvilinear. There were 972 subjects in the low-risk cohort with mean AIx 28% in women (N = 565) and 18% in men (N = 407) (P<0.001). We report the following internally validated reference equations for AIx: men: AIx = 79.20+0.63 (age) 0.002 (age2) 0.28 (heart rate) 0.39 (height). Women: AIx = 56.28 0.90 (age) 0.005 (age2) 0.34 (heart rate) 0.24 (height). AIx appeared to increase with increasing risk of CVD according to HeartScore.ConclusionsWe report a novel and internally validated gender-specific equation including age, heart rate, and height to calculate reference values for AIx.

AB - BackgroundArterial stiffness and pulse wave reflection are associated with cardiovascular disease (CVD). Pulse wave analyses (PWAs) allow the estimation of the central augmentation index (AIx), a measurement of pulse wave reflection. To understand the predictive role of AIx, reference values for AIx are needed.MethodsThis population study is based on 4,561 subjects from The Copenhagen City Heart Study, an ongoing epidemiological survey started in 1976, including subjects randomly chosen from the population in Copenhagen, Denmark. We calculated and internally validated reference values of AIx measured by the SphygmoCor device in a cohort without known CVD or diabetes, and with low risk of CVD according to HeartScore using gender-specific multiple regression analyses adjusting for age, heart rate, and height.ResultsAIx was significantly higher in women than in men, 30% vs. 22%, (P<0.001) and the increase in AIx with age was curvilinear. There were 972 subjects in the low-risk cohort with mean AIx 28% in women (N = 565) and 18% in men (N = 407) (P<0.001). We report the following internally validated reference equations for AIx: men: AIx = 79.20+0.63 (age) 0.002 (age2) 0.28 (heart rate) 0.39 (height). Women: AIx = 56.28 0.90 (age) 0.005 (age2) 0.34 (heart rate) 0.24 (height). AIx appeared to increase with increasing risk of CVD according to HeartScore.ConclusionsWe report a novel and internally validated gender-specific equation including age, heart rate, and height to calculate reference values for AIx.

U2 - 10.1038/ajh.2009.234

DO - 10.1038/ajh.2009.234

M3 - Journal article

SN - 0895-7061

VL - 23

SP - 180

EP - 185

JO - American Journal of Hypertension

JF - American Journal of Hypertension

IS - 2

ER -