TY - JOUR
T1 - Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers
T2 - Improved properties compared to natural AMPs
AU - Olsen, Christian Adam
AU - Ziegler, Hanne Lindvig
AU - Nielsen, Hanne Mørck
AU - Frimodt-Møller, Niels
AU - Jaroszewski, Jerzy W
AU - Franzyk, Henrik
PY - 2010/7/5
Y1 - 2010/7/5
N2 - (Figure Presented) β-Peptoid-peptide hybrid oligomers prepared by efficient Fmoc solid-phase synthesis by using dimeric building blocks were shown to possess antimicrobial activities towards a range of pathogens. Low mammalian cell toxicity and extremely high stability towards enzymatic degradation were additional favorable properties. Notably, lead compounds against P. aeruginosa and C. alb icans were discovered, and potent candidates against E. coli, vancomycin-resistant enterococci, and methicillin-resistant S. aureus were also identified.
AB - (Figure Presented) β-Peptoid-peptide hybrid oligomers prepared by efficient Fmoc solid-phase synthesis by using dimeric building blocks were shown to possess antimicrobial activities towards a range of pathogens. Low mammalian cell toxicity and extremely high stability towards enzymatic degradation were additional favorable properties. Notably, lead compounds against P. aeruginosa and C. alb icans were discovered, and potent candidates against E. coli, vancomycin-resistant enterococci, and methicillin-resistant S. aureus were also identified.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/cbic.201000232
DO - 10.1002/cbic.201000232
M3 - Journal article
C2 - 20503219
SN - 1439-4227
VL - 11
SP - 1356
EP - 1360
JO - ChemBioChem
JF - ChemBioChem
IS - 10
ER -