Antifungal constituents of Melicope borbonica

Henrik Toft Simonsen; Anne Adsersen; Paul Bremner; Michael Heinrich; Ulla Wagner Smitt; Jerzy W Jaroszewski

doi:10.1002/ptr.1482

Antifungal constituents of Melicope borbonica

Henrik Toft Simonsen, Anne Adsersen, Paul Bremner, Michael Heinrich, Ulla Wagner Smitt, Jerzy W Jaroszewski

Plantebiokemi

34 Citationer (Scopus)

Abstract

Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.

Originalsprog	Engelsk
Tidsskrift	Phytotherapy Research
Vol/bind	18
Udgave nummer	7
Sider (fra-til)	542-5
Antal sider	4
ISSN	0951-418X
DOI	https://doi.org/10.1002/ptr.1482
Status	Udgivet - jul. 2004

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10.1002/ptr.1482

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@article{51d055be25884838bc2cdf949de15303,

title = "Antifungal constituents of Melicope borbonica",

abstract = "Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the R{\'e}union Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.",

keywords = "Antifungal Agents, Candida albicans, Humans, Microbial Sensitivity Tests, Penicillium, Phytotherapy, Plant Extracts, Plant Leaves, Rutaceae, Wound Healing",

author = "Simonsen, {Henrik Toft} and Anne Adsersen and Paul Bremner and Michael Heinrich and {Wagner Smitt}, Ulla and Jaroszewski, {Jerzy W}",

year = "2004",

month = jul,

doi = "10.1002/ptr.1482",

language = "English",

volume = "18",

pages = "542--5",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "JohnWiley & Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Antifungal constituents of Melicope borbonica

AU - Simonsen, Henrik Toft

AU - Adsersen, Anne

AU - Bremner, Paul

AU - Heinrich, Michael

AU - Wagner Smitt, Ulla

AU - Jaroszewski, Jerzy W

PY - 2004/7

Y1 - 2004/7

N2 - Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.

AB - Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.

KW - Antifungal Agents

KW - Candida albicans

KW - Humans

KW - Microbial Sensitivity Tests

KW - Penicillium

KW - Phytotherapy

KW - Plant Extracts

KW - Plant Leaves

KW - Rutaceae

KW - Wound Healing

U2 - 10.1002/ptr.1482

DO - 10.1002/ptr.1482

M3 - Journal article

C2 - 15305313

SN - 0951-418X

VL - 18

SP - 542

EP - 545

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 7

ER -

Antifungal constituents of Melicope borbonica

Abstract

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