Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

Chu Chu; Tuo Li; Hans Albert Pedersen; Kenneth Thermann Kongstad; Jizhong Yan; Dan Stærk

doi:10.1016/j.phytol.2019.03.002

Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.

Chu Chu, Tuo Li, Hans Albert Pedersen, Kenneth Thermann Kongstad, Jizhong Yan, Dan Stærk

4 Citationer (Scopus)

Abstract

Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition with high-performance liquid chromatography - photodiode-array detection - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy (HR-bioassay/HPLC-PDA-HRMS-SPE-NMR). Two new compounds, 3,4,4′-trihydroxy-5-methoxybibenzyl (5) and 3,4-dihydroxy-3′,4′,5-trimethoxybibenzyl (8a), along with fourteen known compounds, were identified. Twelve of these were associated with radical scavenging activity, six with α-glucosidase inhibition, and one with α-amylase inhibition. Compound 5, dendrocandin U, and 3,4-dihydroxy-4′,5-dimethoxybibenzyl (12) are reported as α-glucosidase inhibitors for the first time, and 12 is furthermore reported as an α-amylase inhibitor for the first time

Originalsprog	Engelsk
Tidsskrift	Phytochemistry Letters
Vol/bind	31
Sider (fra-til)	47-52
ISSN	1874-3900
DOI	https://doi.org/10.1016/j.phytol.2019.03.002
Status	Udgivet - jun. 2019

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Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis. / Chu, Chu; Li, Tuo; Pedersen, Hans Albert et al.

I: Phytochemistry Letters, Bind 31, 06.2019, s. 47-52.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Antidiabetic constituents of Dendrobium officinale as determined by high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition combined with HPLC-PDA-HRMS-SPE-NMR analysis.",

abstract = "Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition with high-performance liquid chromatography - photodiode-array detection - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy (HR-bioassay/HPLC-PDA-HRMS-SPE-NMR). Two new compounds, 3,4,4′-trihydroxy-5-methoxybibenzyl (5) and 3,4-dihydroxy-3′,4′,5-trimethoxybibenzyl (8a), along with fourteen known compounds, were identified. Twelve of these were associated with radical scavenging activity, six with α-glucosidase inhibition, and one with α-amylase inhibition. Compound 5, dendrocandin U, and 3,4-dihydroxy-4′,5-dimethoxybibenzyl (12) are reported as α-glucosidase inhibitors for the first time, and 12 is furthermore reported as an α-amylase inhibitor for the first time",

author = "Chu Chu and Tuo Li and Pedersen, {Hans Albert} and Kongstad, {Kenneth Thermann} and Jizhong Yan and Dan St{\ae}rk",

year = "2019",

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doi = "10.1016/j.phytol.2019.03.002",

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volume = "31",

pages = "47--52",

journal = "Phytochemistry Letters",

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publisher = "Elsevier",

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AU - Chu, Chu

AU - Li, Tuo

AU - Pedersen, Hans Albert

AU - Kongstad, Kenneth Thermann

AU - Yan, Jizhong

AU - Stærk, Dan

PY - 2019/6

Y1 - 2019/6

N2 - Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition with high-performance liquid chromatography - photodiode-array detection - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy (HR-bioassay/HPLC-PDA-HRMS-SPE-NMR). Two new compounds, 3,4,4′-trihydroxy-5-methoxybibenzyl (5) and 3,4-dihydroxy-3′,4′,5-trimethoxybibenzyl (8a), along with fourteen known compounds, were identified. Twelve of these were associated with radical scavenging activity, six with α-glucosidase inhibition, and one with α-amylase inhibition. Compound 5, dendrocandin U, and 3,4-dihydroxy-4′,5-dimethoxybibenzyl (12) are reported as α-glucosidase inhibitors for the first time, and 12 is furthermore reported as an α-amylase inhibitor for the first time

AB - Type 2 diabetes is a chronic metabolic disorder affecting millions of people worldwide, and new drug leads are urgently needed. The dried stem of Dendrobium officinale is used in China to alleviate the symptoms of diabetes, but investigations of its bioactive components have been limited. We have applied a simple, fast, and effective method, combining triple high-resolution profiling of radical scavenging and α-glucosidase and α-amylase inhibition with high-performance liquid chromatography - photodiode-array detection - high-resolution mass spectrometry - solid-phase extraction - nuclear magnetic resonance spectroscopy (HR-bioassay/HPLC-PDA-HRMS-SPE-NMR). Two new compounds, 3,4,4′-trihydroxy-5-methoxybibenzyl (5) and 3,4-dihydroxy-3′,4′,5-trimethoxybibenzyl (8a), along with fourteen known compounds, were identified. Twelve of these were associated with radical scavenging activity, six with α-glucosidase inhibition, and one with α-amylase inhibition. Compound 5, dendrocandin U, and 3,4-dihydroxy-4′,5-dimethoxybibenzyl (12) are reported as α-glucosidase inhibitors for the first time, and 12 is furthermore reported as an α-amylase inhibitor for the first time

U2 - 10.1016/j.phytol.2019.03.002

DO - 10.1016/j.phytol.2019.03.002

M3 - Journal article

SN - 1874-3900

VL - 31

SP - 47

EP - 52

JO - Phytochemistry Letters

JF - Phytochemistry Letters

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