Anthocyanidins regenerating xanthophylls: a quantum mechanical approach to eye health

Leif Horsfelt Skibsted

doi:10.1016/j.cofs.2018.02.014

Anthocyanidins regenerating xanthophylls: a quantum mechanical approach to eye health

5 Citationer (Scopus)

Abstract

The xanthophylls lutein and zeaxanthin accumulate in human retina and protect vision functions against blue light, singlet oxygen and triplet photosensitizers, but are easily degraded by free radicals involved in lipid oxidation in eye tissue. Polyphenols may regenerate xanthophylls from their initial oxidation products, the carotenoid radical cations, by electron transfer protecting the ‘yellow spot.’ The reorganization energy of the donor/acceptor transition state should equal reaction free energy for optimal diffusion-controlled regeneration of the xanthophylls by polyphenols according to Marcus theory for electron transfer. Anthocyanidins match the reduction potential of xanthophyll radicals in contrast to the more reducing catechins and tocopherols, which overshoot energetically. Quantum mechanics may provide the explanation for the protective effect of blueberry on vision.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Food Science
Vol/bind	20
Sider (fra-til)	24-29
Antal sider	5
ISSN	2214-7993
DOI	https://doi.org/10.1016/j.cofs.2018.02.014
Status	Udgivet - apr. 2018

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10.1016/j.cofs.2018.02.014

Citationsformater

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title = "Anthocyanidins regenerating xanthophylls: a quantum mechanical approach to eye health",

abstract = "The xanthophylls lutein and zeaxanthin accumulate in human retina and protect vision functions against blue light, singlet oxygen and triplet photosensitizers, but are easily degraded by free radicals involved in lipid oxidation in eye tissue. Polyphenols may regenerate xanthophylls from their initial oxidation products, the carotenoid radical cations, by electron transfer protecting the {\textquoteleft}yellow spot.{\textquoteright} The reorganization energy of the donor/acceptor transition state should equal reaction free energy for optimal diffusion-controlled regeneration of the xanthophylls by polyphenols according to Marcus theory for electron transfer. Anthocyanidins match the reduction potential of xanthophyll radicals in contrast to the more reducing catechins and tocopherols, which overshoot energetically. Quantum mechanics may provide the explanation for the protective effect of blueberry on vision.",

author = "Skibsted, {Leif Horsfelt}",

year = "2018",

month = apr,

doi = "10.1016/j.cofs.2018.02.014",

language = "English",

volume = "20",

pages = "24--29",

journal = "Current Opinion in Food Science",

issn = "2214-7993",

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TY - JOUR

T1 - Anthocyanidins regenerating xanthophylls

T2 - a quantum mechanical approach to eye health

AU - Skibsted, Leif Horsfelt

PY - 2018/4

Y1 - 2018/4

N2 - The xanthophylls lutein and zeaxanthin accumulate in human retina and protect vision functions against blue light, singlet oxygen and triplet photosensitizers, but are easily degraded by free radicals involved in lipid oxidation in eye tissue. Polyphenols may regenerate xanthophylls from their initial oxidation products, the carotenoid radical cations, by electron transfer protecting the ‘yellow spot.’ The reorganization energy of the donor/acceptor transition state should equal reaction free energy for optimal diffusion-controlled regeneration of the xanthophylls by polyphenols according to Marcus theory for electron transfer. Anthocyanidins match the reduction potential of xanthophyll radicals in contrast to the more reducing catechins and tocopherols, which overshoot energetically. Quantum mechanics may provide the explanation for the protective effect of blueberry on vision.

AB - The xanthophylls lutein and zeaxanthin accumulate in human retina and protect vision functions against blue light, singlet oxygen and triplet photosensitizers, but are easily degraded by free radicals involved in lipid oxidation in eye tissue. Polyphenols may regenerate xanthophylls from their initial oxidation products, the carotenoid radical cations, by electron transfer protecting the ‘yellow spot.’ The reorganization energy of the donor/acceptor transition state should equal reaction free energy for optimal diffusion-controlled regeneration of the xanthophylls by polyphenols according to Marcus theory for electron transfer. Anthocyanidins match the reduction potential of xanthophyll radicals in contrast to the more reducing catechins and tocopherols, which overshoot energetically. Quantum mechanics may provide the explanation for the protective effect of blueberry on vision.

U2 - 10.1016/j.cofs.2018.02.014

DO - 10.1016/j.cofs.2018.02.014

M3 - Journal article

SN - 2214-7993

VL - 20

SP - 24

EP - 29

JO - Current Opinion in Food Science

JF - Current Opinion in Food Science

ER -

Anthocyanidins regenerating xanthophylls: a quantum mechanical approach to eye health

Abstract

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