Animal models of metabolic and inflammatory diseases

TY - CHAP

T1 - Animal models of metabolic and inflammatory diseases

AU - Hansen, Axel Jacob Kornerup

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Inflammation is a protective attempt by the organism against harmful stimuli. It is important to distinguish between inflammation and infection, because although inflammation may be caused by infectious agents, noninfectious inflammation is the background of a range of diseases, and in this chapter, only this type of inflammation will be considered. Inflammation can be local or systemic, or it can be acute or chronic. Local acute inflammation involves increased movement of plasma and leukocytes, especially neutrophilic granulocytes, from the blood into injured tissues mediated by cells in the local tissue, creating a chemotactic gradient. Such mediators have a short half-life, and therefore the acute inflammation only exists as a cause of a current stimulation. Fibrin and immunoglobulins will also migrate from the vessels, and the subsequent biochemical events mature the inflammatory response, and involve the local vascular system, immune system, and various cells within the injured tissue, such as macrophages, dendritic cells, histiocytes, Kupffer cells, and mastocytes.

AB - Inflammation is a protective attempt by the organism against harmful stimuli. It is important to distinguish between inflammation and infection, because although inflammation may be caused by infectious agents, noninfectious inflammation is the background of a range of diseases, and in this chapter, only this type of inflammation will be considered. Inflammation can be local or systemic, or it can be acute or chronic. Local acute inflammation involves increased movement of plasma and leukocytes, especially neutrophilic granulocytes, from the blood into injured tissues mediated by cells in the local tissue, creating a chemotactic gradient. Such mediators have a short half-life, and therefore the acute inflammation only exists as a cause of a current stimulation. Fibrin and immunoglobulins will also migrate from the vessels, and the subsequent biochemical events mature the inflammatory response, and involve the local vascular system, immune system, and various cells within the injured tissue, such as macrophages, dendritic cells, histiocytes, Kupffer cells, and mastocytes.

KW - Faculty of Health and Medical Sciences

KW - Animal models

KW - Inflammation

KW - Metabolism

KW - Disease

U2 - 10.1201/b16317-7

DO - 10.1201/b16317-7

M3 - Book chapter

SN - 978-1-4665-5512-9

SP - 159

EP - 194

BT - Handbook of laboratory animal science

A2 - Hau, Jann

A2 - Schapiro, Stephen J.

PB - CRC Press

CY - Boca Raton, Fla.

ER -