Angiogenic biomarkers in pregnancy: defining maternal and fetal health

TY - JOUR

T1 - Angiogenic biomarkers in pregnancy

T2 - defining maternal and fetal health

AU - Rasmussen, Lene G

AU - Lykke, Jacob A

AU - Staff, Anne C

N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - We review diagnostic and predictive roles of the angiogenic proteins placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin in preeclampsia, and their association with future cardiovascular disease, diabetes, and breast cancer. Specific patterns of these proteins represent preeclamptic prediction markers and combined with maternal and clinical characteristics, the predictive values increase. Women experiencing preeclampsia have increased risks of developing cardiovascular diseases and diabetes, and a decreased risk of breast cancer. High placental growth factor concentrations have, in elderly patients, been shown to predict cardiovascular events. Diabetes is also a risk factor for future cardiovascular disease. Diabetic vascular complications are associated with increased soluble endoglin concentrations, and vascular endothelial growth factor concentrations are correlated to HbA1c and fasting glucose. Hence dysregulation in angiogenic proteins may link preeclampsia and cardiovascular diseases, targeting women who could in future benefit from prophylactic programs to possibly prevent, delay or reduce cardiovascular disease.

AB - We review diagnostic and predictive roles of the angiogenic proteins placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin in preeclampsia, and their association with future cardiovascular disease, diabetes, and breast cancer. Specific patterns of these proteins represent preeclamptic prediction markers and combined with maternal and clinical characteristics, the predictive values increase. Women experiencing preeclampsia have increased risks of developing cardiovascular diseases and diabetes, and a decreased risk of breast cancer. High placental growth factor concentrations have, in elderly patients, been shown to predict cardiovascular events. Diabetes is also a risk factor for future cardiovascular disease. Diabetic vascular complications are associated with increased soluble endoglin concentrations, and vascular endothelial growth factor concentrations are correlated to HbA1c and fasting glucose. Hence dysregulation in angiogenic proteins may link preeclampsia and cardiovascular diseases, targeting women who could in future benefit from prophylactic programs to possibly prevent, delay or reduce cardiovascular disease.

KW - Antigens, CD

KW - Biomarkers

KW - Female

KW - Fetal Growth Retardation

KW - Humans

KW - Pre-Eclampsia

KW - Predictive Value of Tests

KW - Pregnancy

KW - Pregnancy Proteins

KW - Receptors, Cell Surface

KW - Vascular Endothelial Growth Factor Receptor-1

U2 - 10.1111/aogs.12629

DO - 10.1111/aogs.12629

M3 - Review

C2 - 25753566

SN - 0001-6349

VL - 94

SP - 820

EP - 832

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 8

ER -