Ancient genomics

Clio Der Sarkissian; Morten Erik Allentoft; Maria del Carmen Avila Arcos; Ross Barnett; Paula F. Campos; Enrico Cappellini; Luca Ermini; Rut Fernandez Garcia; Rute Andreia Rodrigues da Fonseca; Aurélien Ginolhac; Anders Johannes Hansen; Hákon Jónsson; Thorfinn Sand Korneliussen; Ashot Margaryan; Michael David Martin; José Victor Moreno Mayar; Maanasa Raghavan; Morten Rasmussen; Marcela Sandoval Velasco; Hannes Schroeder; Mikkel Schubert; Andaine Seguin-Orlando; Nathan Wales; M. Thomas P. Gilbert; Eske Willerslev; Ludovic Antoine Alexandre Orlando

doi:10.1098/rstb.2013.0387

Ancient genomics

Clio Der Sarkissian, Morten Erik Allentoft, Maria del Carmen Avila Arcos, Ross Barnett, Paula F. Campos, Enrico Cappellini, Luca Ermini, Rut Fernandez Garcia, Rute Andreia Rodrigues da Fonseca, Aurélien Ginolhac, Anders Johannes Hansen, Hákon Jónsson, Thorfinn Sand Korneliussen, Ashot Margaryan, Michael David Martin, José Victor Moreno Mayar, Maanasa Raghavan, Morten Rasmussen, Marcela Sandoval Velasco, Hannes SchroederMikkel Schubert, Andaine Seguin-Orlando, Nathan Wales, M. Thomas P. Gilbert, Eske Willerslev, Ludovic Antoine Alexandre Orlando

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Abstract

The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.

Originalsprog	Engelsk
Artikelnummer	20130387
Tidsskrift	Philosophical Transactions of the Royal Society B: Biological Sciences
Vol/bind	370
Udgave nummer	1660
Antal sider	12
ISSN	0962-8436
DOI	https://doi.org/10.1098/rstb.2013.0387
Status	Udgivet - 19 jan. 2015

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10.1098/rstb.2013.0387Licens: CC BY

Sarkissian_2015_Ancient_genomicsForlagets udgivne version, 943 KBLicens: CC BY

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Der Sarkissian, C., Allentoft, M. E., Avila Arcos, M. D. C., Barnett, R., Campos, P. F., Cappellini, E., Ermini, L., Fernandez Garcia, R., Rodrigues da Fonseca, R. A., Ginolhac, A., Hansen, A. J., Jónsson, H., Korneliussen, T. S., Margaryan, A., Martin, M. D., Moreno Mayar, J. V., Raghavan, M., Rasmussen, M., Sandoval Velasco, M., ... Orlando, L. A. A. (2015). Ancient genomics. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1660), Artikel 20130387. https://doi.org/10.1098/rstb.2013.0387

Der Sarkissian, C, Allentoft, ME, Avila Arcos, MDC, Barnett, R, Campos, PF, Cappellini, E, Ermini, L, Fernandez Garcia, R, Rodrigues da Fonseca, RA, Ginolhac, A, Hansen, AJ, Jónsson, H, Korneliussen, TS , Margaryan, A, Martin, MD, Moreno Mayar, JV, Raghavan, M, Rasmussen, M, Sandoval Velasco, M , Schroeder, H, Schubert, M, Seguin-Orlando, A, Wales, N, Gilbert, MTP , Willerslev, E & Orlando, LAA 2015, 'Ancient genomics', Philosophical Transactions of the Royal Society B: Biological Sciences, bind 370, nr. 1660, 20130387. https://doi.org/10.1098/rstb.2013.0387

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abstract = "The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.",

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AU - Der Sarkissian, Clio

AU - Allentoft, Morten Erik

AU - Avila Arcos, Maria del Carmen

AU - Barnett, Ross

AU - Campos, Paula F.

AU - Cappellini, Enrico

AU - Ermini, Luca

AU - Fernandez Garcia, Rut

AU - Rodrigues da Fonseca, Rute Andreia

AU - Ginolhac, Aurélien

AU - Hansen, Anders Johannes

AU - Jónsson, Hákon

AU - Korneliussen, Thorfinn Sand

AU - Margaryan, Ashot

AU - Martin, Michael David

AU - Moreno Mayar, José Victor

AU - Raghavan, Maanasa

AU - Rasmussen, Morten

AU - Sandoval Velasco, Marcela

AU - Schroeder, Hannes

AU - Schubert, Mikkel

AU - Seguin-Orlando, Andaine

AU - Wales, Nathan

AU - Gilbert, M. Thomas P.

AU - Willerslev, Eske

AU - Orlando, Ludovic Antoine Alexandre

PY - 2015/1/19

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N2 - The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.

AB - The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.

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DO - 10.1098/rstb.2013.0387

M3 - Review

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JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

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Ancient genomics

Abstract

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