An updated review on primary signet-ring cell carcinoma of the urinary bladder and report of a case

TY - JOUR

T1 - An updated review on primary signet-ring cell carcinoma of the urinary bladder and report of a case

AU - Lendorf, Maria Elisabeth

AU - Dohn, Line Hammer

AU - Á Dunga, Bara

AU - Loya, Anand C

AU - Pappot, Helle

PY - 2018/3/4

Y1 - 2018/3/4

N2 - OBJECTIVE: The aim of the present study was to emphasize the critical importance of the clinician's awareness of signet-ring cell carcinoma (SRCC) of the urinary bladder, a rare and aggressive disease entity.MATERIALS AND METHODS: A review of the current literature was conducted and a classic case of advanced SRCC of the urinary bladder is reported, clearly demonstrating the severity of this disease and the imperative need for standardized recommendations for the diagnostic work-up and management of urinary bladder SRCC.RESULTS: The prognosis for patients with SRCC of the urinary bladder is poor, attributed to presentation at advanced stages following asymptomatic progression, inefficacy of multimodality therapy and possibly an aggressive underlying biological phenotype. Treatment options are limited and not well studied.CONCLUSION: Given the rarity of SRCC, multi-institutional clinical trials and international cooperation are mandatory to improve survival for patients with primary SRCC of the bladder.

AB - OBJECTIVE: The aim of the present study was to emphasize the critical importance of the clinician's awareness of signet-ring cell carcinoma (SRCC) of the urinary bladder, a rare and aggressive disease entity.MATERIALS AND METHODS: A review of the current literature was conducted and a classic case of advanced SRCC of the urinary bladder is reported, clearly demonstrating the severity of this disease and the imperative need for standardized recommendations for the diagnostic work-up and management of urinary bladder SRCC.RESULTS: The prognosis for patients with SRCC of the urinary bladder is poor, attributed to presentation at advanced stages following asymptomatic progression, inefficacy of multimodality therapy and possibly an aggressive underlying biological phenotype. Treatment options are limited and not well studied.CONCLUSION: Given the rarity of SRCC, multi-institutional clinical trials and international cooperation are mandatory to improve survival for patients with primary SRCC of the bladder.

KW - Carcinoma, Signet Ring Cell/diagnosis

KW - Combined Modality Therapy

KW - Disease Progression

KW - Fatal Outcome

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Prognosis

KW - Urinary Bladder Neoplasms/diagnosis

U2 - 10.1080/21681805.2017.1418020

DO - 10.1080/21681805.2017.1418020

M3 - Review

C2 - 29291665

SN - 0036-5599

VL - 52

SP - 87

EP - 93

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

IS - 2

ER -