An overview of the synergy and crosstalk between pentraxins and collectins/ficolins: their functional relevance in complement activation

TY - JOUR

T1 - An overview of the synergy and crosstalk between pentraxins and collectins/ficolins

T2 - their functional relevance in complement activation

AU - Ma, Ying Jie

AU - Lee, Bok Luel

AU - Garred, Peter

PY - 2017/4/7

Y1 - 2017/4/7

N2 - The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation.

AB - The complement system is an innate immune defense machinery comprising components that deploy rapid immune responses and provide efficient protection against foreign invaders and unwanted host elements. The complement system is activated upon recognition of pathogenic microorganisms or altered self-cells by exclusive pattern recognition molecules (PRMs), such as collectins, ficolins and pentraxins. Recent accumulating evidence shows that the different classes of effector PRMs build up a co-operative network and exert synergistic effects on complement activation. In this review, we describe our updated view of the crosstalk between previously unlinked PRMs in complement activation and the potential pathogenic effects during infection and inflammation.

KW - Journal Article

KW - Review

U2 - 10.1038/emm.2017.51

DO - 10.1038/emm.2017.51

M3 - Review

C2 - 28428631

SN - 1226-3613

VL - 49

JO - Experimental & Molecular Medicine

JF - Experimental & Molecular Medicine

M1 - e320

ER -