@article{7922b0c0a75c11debc73000ea68e967b,
title = "An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme",
abstract = "Twin-ribozyme introns are formed by two ribozymes belonging to the group I family and occur in some ribosomal RNA transcripts. The group I-like ribozyme, GIR1, liberates the 5' end of a homing endonuclease messenger RNA in the slime mold Didymium iridis. We demonstrate that this cleavage occurs by a transesterification reaction with the joining of the first and the third nucleotide of the messenger by a 2',5'-phosphodiester linkage. Thus, a group I-like ribozyme catalyzes an RNA branching reaction similar to the first step of splicing in group II introns and spliceosomal introns. The resulting short lariat, by forming a protective 5' cap, might have been useful in a primitive RNA world.",
author = "Henrik Nielsen and Eric Westhof and Steinar Johansen",
note = "Keywords: Base Sequence; Catalysis; Endonucleases; Esterification; Introns; Molecular Sequence Data; RNA Caps; RNA Splicing; RNA, Catalytic",
year = "2005",
doi = "10.1126/science.1113645",
language = "English",
volume = "309",
pages = "1584--7",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5740",
}