An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes

Therese Lindvall; Kutty Selva Nandakumar; Kimia  Yousefi; Rikard Holmdahl; Åsa Andersson

doi:10.1016/j.jneuroim.2011.04.001

An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes

Therese Lindvall, Kutty Selva Nandakumar, Kimia Yousefi, Rikard Holmdahl, Åsa Andersson

1 Citationer (Scopus)

Abstract

A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4⁺ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
Vol/bind	235
Udgave nummer	1-2
Sider (fra-til)	40-47
DOI	https://doi.org/10.1016/j.jneuroim.2011.04.001
Status	Udgivet - jun. 2011

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10.1016/j.jneuroim.2011.04.001

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title = "An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes",

abstract = "A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.",

author = "Therese Lindvall and {Selva Nandakumar}, Kutty and Kimia Yousefi and Rikard Holmdahl and {\AA}sa Andersson",

year = "2011",

month = jun,

doi = "10.1016/j.jneuroim.2011.04.001",

language = "English",

volume = "235",

pages = "40--47",

journal = "Journal of Neuroimmunology",

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T1 - An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes

AU - Lindvall, Therese

AU - Selva Nandakumar, Kutty

AU - Yousefi, Kimia

AU - Holmdahl, Rikard

AU - Andersson, Åsa

PY - 2011/6

Y1 - 2011/6

N2 - A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.

AB - A locus on mouse chromosome 16 was found to control experimental autoimmune encephalomyelitis (EAE) in studies using congenic mice. Genes within the congenic region control encephalomyelitis but not arthritis, indicating the presence of genes in this region involved in central nervous system (CNS) specific mechanisms. Flow cytometry analyses of expression of two candidate genes within the linked locus, Cd200 and Btla, demonstrated a significantly lower expression of CD200 on CD4+ T cells and higher expression of BTLA on B cells from the congenic mice. These results suggest that genes within this mouse chromosome 16 locus specifically control EAE development possibly through immune-regulatory cell-surface molecules.

U2 - 10.1016/j.jneuroim.2011.04.001

DO - 10.1016/j.jneuroim.2011.04.001

M3 - Journal article

C2 - 21543122

SN - 1872-8421

VL - 235

SP - 40

EP - 47

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes

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