An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders

TY - JOUR

T1 - An auditory Go/No-Go study of event-related potentials in children with fetal alcohol spectrum disorders

AU - Steinmann, Tobias P

AU - Andrew, Colin M

AU - Thomsen, Carsten E

AU - Kjær, Troels W

AU - Meintjes, Ernesta M

AU - Molteno, Christopher D

AU - Jacobson, Joseph B

AU - Jacobson, Sandra W

AU - Sorensen, Helge B D

PY - 2011

Y1 - 2011

N2 - In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12.8 years (11 years to 14.7 years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n = 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n = 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.

AB - In this study event-related potentials (ERPs) were used to investigate the effects of prenatal alcohol exposure on response inhibition identified during task performance. ERPs were recorded during a auditory Go/No Go task in two groups of children with mean age of 12.8 years (11 years to 14.7 years): one diagnosed with fetal alcohol syndrome (FAS) or partial FAS (FAS/PFAS; n = 12) and a control group of children of same age whose mothers abstained from alcohol or drank minimally during pregnancy (n = 11). The children were instructed to push a button in response to the Go stimulus and not to press the button when the No Go stimulus were heard. Task performance accuracy did not differ between the two groups, however differences were observed in the ERP components: P2, N2, and P3. The P2 amplitude were larger for Go trials in both groups. The FAS/PFAS group showed slower N2 response to Go trials, suggesting a less efficient early classification of the stimulus. P3 showed larger amplitudes to No-Go vs. Go in both groups. The study has provided new evidence for inhibition deficits in FAS/PFAS subjects identified by ERPs.

KW - Adolescent

KW - Auditory Perception

KW - Brain Mapping

KW - Child

KW - Decision Making

KW - Evoked Potentials, Auditory

KW - Female

KW - Fetal Alcohol Syndrome

KW - Humans

KW - Male

KW - Pregnancy

KW - Task Performance and Analysis

U2 - 10.1109/IEMBS.2011.6090181

DO - 10.1109/IEMBS.2011.6090181

M3 - Journal article

C2 - 22254429

SN - 2375-7477

VL - 2011

SP - 789

EP - 792

JO - I E E E Engineering in Medicine and Biology Society. Conference Proceedings

JF - I E E E Engineering in Medicine and Biology Society. Conference Proceedings

ER -