An alternative anionic bio-sustainable anti-fungal agent: investigation of its mode of action on the fungal cell membrane

TY - JOUR

T1 - An alternative anionic bio-sustainable anti-fungal agent

T2 - investigation of its mode of action on the fungal cell membrane

AU - Stenbæk, Jonas

AU - Löf, David

AU - Falkman, Peter

AU - Jensen, Bo

AU - Cárdenas, Marité

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The potential of a lactylate (the sodium caproyl lactylate or C10 lactylate), a typical food grade emulsifier, as an anionic environmental friendly anti-fungal additive was tested in growth medium and formulated in a protective coating for exterior wood. Different laboratory growth tests on the blue stain fungus Aureobasidium pullulans were performed and its interactions on a model fungal cell membrane were studied. Promising short term anti-fungal effects in growth tests were observed, although significant but less dramatic effects took place in coating test on wood panels. Scanning electron microscope analysis shows clear differences in the amount of fungal slime on the mycelium of Aureobasidium pullulans when the fungus was exposed of C10 lactylate. This could indicate an effect on the pullulan and melanin production by the fungus. Moreover, the interaction studies on model fungal cell membranes show that C10 lactylate affects the phospholipid bilayer in a similar manner to other negative charged detergents.

AB - The potential of a lactylate (the sodium caproyl lactylate or C10 lactylate), a typical food grade emulsifier, as an anionic environmental friendly anti-fungal additive was tested in growth medium and formulated in a protective coating for exterior wood. Different laboratory growth tests on the blue stain fungus Aureobasidium pullulans were performed and its interactions on a model fungal cell membrane were studied. Promising short term anti-fungal effects in growth tests were observed, although significant but less dramatic effects took place in coating test on wood panels. Scanning electron microscope analysis shows clear differences in the amount of fungal slime on the mycelium of Aureobasidium pullulans when the fungus was exposed of C10 lactylate. This could indicate an effect on the pullulan and melanin production by the fungus. Moreover, the interaction studies on model fungal cell membranes show that C10 lactylate affects the phospholipid bilayer in a similar manner to other negative charged detergents.

U2 - 10.1016/j.jcis.2017.03.018

DO - 10.1016/j.jcis.2017.03.018

M3 - Journal article

C2 - 28285052

SN - 0021-9797

VL - 497

SP - 242

EP - 248

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

ER -