TY - JOUR
T1 - Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model
AU - Sattler, Stefan M.
AU - Lubberding, Anniek F.
AU - Skibsbye, Lasse
AU - Jabbari, Reza
AU - Wakili, Reza
AU - Jespersen, Thomas
AU - Tfelt-Hansen, Jacob
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.
AB - Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after onset of AMI reduced the incidence of VF in a porcine model. Eighteen female Danish landrace pigs were randomized to a control and an amiodarone group. AMI was induced by ligation of the mid-left anterior descending artery for 120 min followed by 60 min of reperfusion. VF occurred in 0/8 pigs treated with amiodarone compared to 7/10 controls (P < 0.01). Amiodarone treatment prolonged RR intervals, reduced dispersion of action potential duration in the infarcted area and mean number of ectopic beats. No negative effects on cardiac output and blood pressure were observed with amiodarone. Amiodarone qualifies as a potential drug candidate to prevent VF in the first minutes to hours of AMI.
KW - Acute myocardial infarction
KW - Amiodarone
KW - Animal model
KW - Sudden cardiac death
KW - Ventricular fibrillation
UR - http://www.scopus.com/inward/record.url?scp=85059606817&partnerID=8YFLogxK
U2 - 10.1007/s12265-018-9861-6
DO - 10.1007/s12265-018-9861-6
M3 - Journal article
C2 - 30617762
AN - SCOPUS:85059606817
SN - 1937-5387
VL - 12
SP - 321
EP - 330
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 4
ER -