Amination of aryl iodides using a fluorous-tagged ammonia equivalent

Simon Dalsgaard Nielsen; Garrick Smith; Mikael Begtrup; Jesper Langgaard Kristensen

doi:10.1002/ejoc.201000367

Amination of aryl iodides using a fluorous-tagged ammonia equivalent

Simon Dalsgaard Nielsen, Garrick Smith, Mikael Begtrup, Jesper Langgaard Kristensen

11 Citationer (Scopus)

Abstract

A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous SolidPhase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products.

Originalsprog	Engelsk
Tidsskrift	European Journal of Organic Chemistry
Vol/bind	2010
Udgave nummer	19
Sider (fra-til)	3704-3710
ISSN	1434-193X
DOI	https://doi.org/10.1002/ejoc.201000367
Status	Udgivet - jul. 2010

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10.1002/ejoc.201000367

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title = "Amination of aryl iodides using a fluorous-tagged ammonia equivalent",

abstract = "A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous SolidPhase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Nielsen, {Simon Dalsgaard} and Garrick Smith and Mikael Begtrup and Kristensen, {Jesper Langgaard}",

note = "Keywords: Amination; Ammonia equivalent; Fluorous synthesis; N-O linker",

year = "2010",

month = jul,

doi = "10.1002/ejoc.201000367",

language = "English",

volume = "2010",

pages = "3704--3710",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",

number = "19",

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TY - JOUR

T1 - Amination of aryl iodides using a fluorous-tagged ammonia equivalent

AU - Nielsen, Simon Dalsgaard

AU - Smith, Garrick

AU - Begtrup, Mikael

AU - Kristensen, Jesper Langgaard

N1 - Keywords: Amination; Ammonia equivalent; Fluorous synthesis; N-O linker

PY - 2010/7

Y1 - 2010/7

N2 - A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous SolidPhase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products.

AB - A fluorous-tagged ammonia equivalent for the Cu-catalyzed amination of aryl iodides is described in which N-Boc-protected anilines are produced in high overall yield and purity. All purification steps are performed using Fluorous SolidPhase Extraction (F-SPE) greatly simplifying and speeding up the isolation of the desired products.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/ejoc.201000367

DO - 10.1002/ejoc.201000367

M3 - Journal article

SN - 1434-193X

VL - 2010

SP - 3704

EP - 3710

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 19

ER -

Amination of aryl iodides using a fluorous-tagged ammonia equivalent

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