Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

Helle Bach Søndergaard; Finn Sellebjerg; Jan Hillert; Tomas Olsson; Ingrid Kockum; Magdalena Lindén; Inger-Lise Mero; Kjell-Morten Myhr; Elisabeth G Celius; Hanne F Harbo; Jeppe Romme Christensen; Lars Börnsen; Per Soelberg Sørensen; Annette Bang Oturai

doi:http://dx.doi.org/10.1038/ejhg.2011.88

Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

Helle Bach Søndergaard, Finn Sellebjerg, Jan Hillert, Tomas Olsson, Ingrid Kockum, Magdalena Lindén, Inger-Lise Mero, Kjell-Morten Myhr, Elisabeth G Celius, Hanne F Harbo, Jeppe Romme Christensen, Lars Börnsen, Per Soelberg Sørensen, Annette Bang Oturai

Institut for Klinisk Medicin

5 Citationer (Scopus)

Abstract

Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P0.046, odds ratio1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P0.001), and the KLRB1 expression decreased significantly (P0.001) after interferon (IFN)-Β treatment. KLRB1 was expressed in T and natural killer (NK) cells, and expression mainly decreased in NK cells in patients treated with IFN-Β. Collectively, our results indicate that KLRB1 gene expression is altered in MS and likely to be involved in the pathogenesis of the disease, whereas rs4763655 in KLRB1 seems to have a minimal role in MS susceptibility.

Originalsprog	Engelsk
Tidsskrift	European Journal of Human Genetics
Vol/bind	19
Udgave nummer	10
Sider (fra-til)	1100-3
Antal sider	4
ISSN	1018-4813
DOI	https://doi.org/10.1038/ejhg.2011.88
Status	Udgivet - okt. 2011

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http://dx.doi.org/10.1038/ejhg.2011.88

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Søndergaard, H. B., Sellebjerg, F., Hillert, J., Olsson, T., Kockum, I., Lindén, M., Mero, I-L., Myhr, K-M., Celius, E. G., Harbo, H. F., Christensen, J. R., Börnsen, L., Sørensen, P. S., & Oturai, A. B. (2011). Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655. European Journal of Human Genetics, 19(10), 1100-3. https://doi.org/10.1038/ejhg.2011.88

Søndergaard, HB, Sellebjerg, F, Hillert, J, Olsson, T, Kockum, I, Lindén, M, Mero, I-L, Myhr, K-M, Celius, EG, Harbo, HF, Christensen, JR, Börnsen, L, Sørensen, PS & Oturai, AB 2011, 'Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655', European Journal of Human Genetics, bind 19, nr. 10, s. 1100-3. https://doi.org/10.1038/ejhg.2011.88

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title = "Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655",

abstract = "Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P0.046, odds ratio1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P0.001), and the KLRB1 expression decreased significantly (P0.001) after interferon (IFN)-Β treatment. KLRB1 was expressed in T and natural killer (NK) cells, and expression mainly decreased in NK cells in patients treated with IFN-Β. Collectively, our results indicate that KLRB1 gene expression is altered in MS and likely to be involved in the pathogenesis of the disease, whereas rs4763655 in KLRB1 seems to have a minimal role in MS susceptibility.",

author = "S{\o}ndergaard, {Helle Bach} and Finn Sellebjerg and Jan Hillert and Tomas Olsson and Ingrid Kockum and Magdalena Lind{\'e}n and Inger-Lise Mero and Kjell-Morten Myhr and Celius, {Elisabeth G} and Harbo, {Hanne F} and Christensen, {Jeppe Romme} and Lars B{\"o}rnsen and S{\o}rensen, {Per Soelberg} and Oturai, {Annette Bang}",

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T1 - Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

AU - Søndergaard, Helle Bach

AU - Sellebjerg, Finn

AU - Hillert, Jan

AU - Olsson, Tomas

AU - Kockum, Ingrid

AU - Lindén, Magdalena

AU - Mero, Inger-Lise

AU - Myhr, Kjell-Morten

AU - Celius, Elisabeth G

AU - Harbo, Hanne F

AU - Christensen, Jeppe Romme

AU - Börnsen, Lars

AU - Sørensen, Per Soelberg

AU - Oturai, Annette Bang

PY - 2011/10

Y1 - 2011/10

N2 - Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P0.046, odds ratio1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P0.001), and the KLRB1 expression decreased significantly (P0.001) after interferon (IFN)-Β treatment. KLRB1 was expressed in T and natural killer (NK) cells, and expression mainly decreased in NK cells in patients treated with IFN-Β. Collectively, our results indicate that KLRB1 gene expression is altered in MS and likely to be involved in the pathogenesis of the disease, whereas rs4763655 in KLRB1 seems to have a minimal role in MS susceptibility.

AB - Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P0.046, odds ratio1.06 (1.00-1.13)) in a large Scandinavian case-control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P0.001), and the KLRB1 expression decreased significantly (P0.001) after interferon (IFN)-Β treatment. KLRB1 was expressed in T and natural killer (NK) cells, and expression mainly decreased in NK cells in patients treated with IFN-Β. Collectively, our results indicate that KLRB1 gene expression is altered in MS and likely to be involved in the pathogenesis of the disease, whereas rs4763655 in KLRB1 seems to have a minimal role in MS susceptibility.

U2 - http://dx.doi.org/10.1038/ejhg.2011.88

DO - http://dx.doi.org/10.1038/ejhg.2011.88

M3 - Journal article

SN - 1018-4813

VL - 19

SP - 1100

EP - 1103

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 10

ER -

Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655

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