Alteration in pancreatic islet function in human immunodeficiency virus

Steen B Haugaard

doi:10.1016/j.ecl.2014.06.004

Alteration in pancreatic islet function in human immunodeficiency virus

Institut for Klinisk Medicin

Abstract

Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.

Originalsprog	Engelsk
Tidsskrift	Endocrinology & Metabolism Clinics of North America
Vol/bind	43
Udgave nummer	3
Sider (fra-til)	697-708
Antal sider	12
ISSN	0889-8529
DOI	https://doi.org/10.1016/j.ecl.2014.06.004
Status	Udgivet - sep. 2014

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10.1016/j.ecl.2014.06.004

Citationsformater

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title = "Alteration in pancreatic islet function in human immunodeficiency virus",

abstract = "Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.",

keywords = "Carbamates, HIV Protease Inhibitors, HIV-Associated Lipodystrophy Syndrome, Humans, Indinavir, Insulin, Insulin Resistance, Insulin-Secreting Cells, Nelfinavir, Ritonavir, Sulfonamides",

author = "Haugaard, {Steen B}",

year = "2014",

month = sep,

doi = "10.1016/j.ecl.2014.06.004",

language = "English",

volume = "43",

pages = "697--708",

journal = "Endocrinology and Metabolism Clinics of North America",

issn = "0889-8529",

publisher = "W.B.Saunders Co.",

number = "3",

}

TY - JOUR

T1 - Alteration in pancreatic islet function in human immunodeficiency virus

AU - Haugaard, Steen B

PY - 2014/9

Y1 - 2014/9

N2 - Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.

AB - Molecular mechanisms behind the defects in insulin production and secretion associated with antihuman immunodeficiency virus (anti-HIV) therapy and the development of HIV-associated lipodystrophy syndrome (HALS) are discussed in this article. Data suggesting insulin resistance on the beta cell and defects in first-phase insulin release of HALS patients are presented. Hepatic extraction of insulin, nonglucose insulin secretagogues and insulin-like growth factor release may exert influence on the demand of circulating insulin and on insulin secretion in HIV-infected patients. Finally, the paucity in understanding the incretin effects in HIV and HIV therapy in relation to insulin secretion is highlighted.

KW - Carbamates

KW - HIV Protease Inhibitors

KW - HIV-Associated Lipodystrophy Syndrome

KW - Humans

KW - Indinavir

KW - Insulin

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Nelfinavir

KW - Ritonavir

KW - Sulfonamides

U2 - 10.1016/j.ecl.2014.06.004

DO - 10.1016/j.ecl.2014.06.004

M3 - Journal article

C2 - 25169562

SN - 0889-8529

VL - 43

SP - 697

EP - 708

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 3

ER -

Alteration in pancreatic islet function in human immunodeficiency virus

Abstract

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