Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics

TY - JOUR

T1 - Alpine Skiing With total knee ArthroPlasty (ASWAP)

T2 - metabolism, inflammation, and skeletal muscle fiber characteristics

AU - Kristensen, M.

AU - Pötzelsberger, B.

AU - Scheiber, P.

AU - Bergdahl, A.

AU - Hansen, C. N.

AU - Andersen, J. L.

AU - Narici, M.

AU - Salvioli, S.

AU - Conte, M.

AU - Müller, E.

AU - Dela, F.

N1 - © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty-three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non-operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA.

AB - We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty-three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non-operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA.

KW - Aged

KW - Arthroplasty, Replacement, Knee

KW - Blood Glucose

KW - C-Reactive Protein

KW - Capillaries

KW - Cholesterol, HDL

KW - Cholesterol, LDL

KW - Cytokines

KW - Female

KW - Glycogen

KW - Humans

KW - Inflammation

KW - Insulin

KW - Male

KW - Middle Aged

KW - Mitochondrial Proteins

KW - Muscle Fibers, Skeletal

KW - Muscle Fibers, Slow-Twitch

KW - Muscle, Skeletal

KW - Osteoarthritis, Knee

KW - Skiing

KW - Triglycerides

U2 - 10.1111/sms.12478

DO - 10.1111/sms.12478

M3 - Journal article

C2 - 26083701

SN - 0905-7188

VL - 25

SP - 40

EP - 48

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

IS - Supplement S2

ER -