Allergy assessment of foods or ingredients derived from biotechnology, gene-modified organisms, or novel foods

Lars K. Poulsen

doi:10.1002/mnfr.200400029

Allergy assessment of foods or ingredients derived from biotechnology, gene-modified organisms, or novel foods

93 Citationer (Scopus)

Abstract

The introduction of novel proteins into foods carries a risk of eliciting allergic reactions in individuals sensitive to the introduced protein and a risk of sensitizing susceptible individuals. No single predictive test exists to perform a hazard assessment in relation to allergenic properties of newly expressed proteins in gene-modified organisms (GMOs). Instead, performance of a weighted risk analysis based on the decision tree approach has been suggested. The individual steps of this analysis comprise sequence homology to known allergens, specific or targeted serum screens for immunoglobulin E (IgE) cross-reactions to known allergens, digestability studies of the proteins in simulated gastric and/or intestinal fluids, and animal studies. These steps are discussed and five examples of risk evaluation of GMOs or novel foods are presented. These include ice-structuring protein derived from fish, microbial transglutaminase, GMO-soybeans, amylase and the Nangai nut.

Originalsprog	Engelsk
Tidsskrift	Molecular Nutrition & Food Research
Vol/bind	48
Udgave nummer	6
Sider (fra-til)	413-23
Antal sider	11
ISSN	1613-4125
DOI	https://doi.org/10.1002/mnfr.200400029
Status	Udgivet - nov. 2004

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10.1002/mnfr.200400029

Citationsformater

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title = "Allergy assessment of foods or ingredients derived from biotechnology, gene-modified organisms, or novel foods",

abstract = "The introduction of novel proteins into foods carries a risk of eliciting allergic reactions in individuals sensitive to the introduced protein and a risk of sensitizing susceptible individuals. No single predictive test exists to perform a hazard assessment in relation to allergenic properties of newly expressed proteins in gene-modified organisms (GMOs). Instead, performance of a weighted risk analysis based on the decision tree approach has been suggested. The individual steps of this analysis comprise sequence homology to known allergens, specific or targeted serum screens for immunoglobulin E (IgE) cross-reactions to known allergens, digestability studies of the proteins in simulated gastric and/or intestinal fluids, and animal studies. These steps are discussed and five examples of risk evaluation of GMOs or novel foods are presented. These include ice-structuring protein derived from fish, microbial transglutaminase, GMO-soybeans, amylase and the Nangai nut.",

keywords = "Allergens, Animals, Biotechnology, Decision Trees, Food Hypersensitivity, Humans, Immunoglobulin E, Models, Animal, Organisms, Genetically Modified, Proteins, Safety, Sequence Homology, Amino Acid",

author = "Poulsen, {Lars K.}",

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AU - Poulsen, Lars K.

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N2 - The introduction of novel proteins into foods carries a risk of eliciting allergic reactions in individuals sensitive to the introduced protein and a risk of sensitizing susceptible individuals. No single predictive test exists to perform a hazard assessment in relation to allergenic properties of newly expressed proteins in gene-modified organisms (GMOs). Instead, performance of a weighted risk analysis based on the decision tree approach has been suggested. The individual steps of this analysis comprise sequence homology to known allergens, specific or targeted serum screens for immunoglobulin E (IgE) cross-reactions to known allergens, digestability studies of the proteins in simulated gastric and/or intestinal fluids, and animal studies. These steps are discussed and five examples of risk evaluation of GMOs or novel foods are presented. These include ice-structuring protein derived from fish, microbial transglutaminase, GMO-soybeans, amylase and the Nangai nut.

AB - The introduction of novel proteins into foods carries a risk of eliciting allergic reactions in individuals sensitive to the introduced protein and a risk of sensitizing susceptible individuals. No single predictive test exists to perform a hazard assessment in relation to allergenic properties of newly expressed proteins in gene-modified organisms (GMOs). Instead, performance of a weighted risk analysis based on the decision tree approach has been suggested. The individual steps of this analysis comprise sequence homology to known allergens, specific or targeted serum screens for immunoglobulin E (IgE) cross-reactions to known allergens, digestability studies of the proteins in simulated gastric and/or intestinal fluids, and animal studies. These steps are discussed and five examples of risk evaluation of GMOs or novel foods are presented. These include ice-structuring protein derived from fish, microbial transglutaminase, GMO-soybeans, amylase and the Nangai nut.

KW - Allergens

KW - Animals

KW - Biotechnology

KW - Decision Trees

KW - Food Hypersensitivity

KW - Humans

KW - Immunoglobulin E

KW - Models, Animal

KW - Organisms, Genetically Modified

KW - Proteins

KW - Safety

KW - Sequence Homology, Amino Acid

U2 - 10.1002/mnfr.200400029

DO - 10.1002/mnfr.200400029

M3 - Journal article

C2 - 15508176

SN - 1613-4125

VL - 48

SP - 413

EP - 423

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 6

ER -

Allergy assessment of foods or ingredients derived from biotechnology, gene-modified organisms, or novel foods

Abstract

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