Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

TY - JOUR

T1 - Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

AU - Gyan, B A

AU - Goka, B

AU - Cvetkovic, J T

AU - Kurtzhals, J L

AU - Adabayeri, V

AU - Perlmann, H

AU - Lefvert, A-K

AU - Akanmori, B D

AU - Troye-Blomberg, M

N1 - Keywords: Alleles; Antibodies, Protozoan; Child; Child, Preschool; Gene Frequency; Genotype; Ghana; Humans; Immunoglobulin E; Infant; Interleukin-4; Linkage Disequilibrium; Malaria, Cerebral; Malaria, Falciparum; Parasitemia; Polymorphism, Genetic; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Severity of Illness Index

PY - 2004

Y1 - 2004

N2 - Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.

AB - Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.

U2 - 10.1111/j.1365-2249.2004.02590.x

DO - 10.1111/j.1365-2249.2004.02590.x

M3 - Journal article

C2 - 15373917

SN - 0964-2536

VL - 138

SP - 145

EP - 150

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

IS - 1

ER -