ALG-2, a multifunctional calcium binding protein?

Svetlana Tarabykina, Jens Mollerup, P. Winding Gojkovic, Martin Werner Berchtold

33 Citationer (Scopus)

Abstract

Udgivelsesdato: May 1, 2004

Originalsprog	Engelsk
Tidsskrift	Frontiers in Bioscience
Vol/bind	9
Sider (fra-til)	1817-1832
ISSN	1093-9946
Status	Udgivet - 2004

Adgang til dokumentet

http://www.bioscience.org/2004/v9/af/1358/fulltext.htm

Citationsformater

@article{ab290ac074c311dbbee902004c4f4f50,

title = "ALG-2, a multifunctional calcium binding protein?",

abstract = "ALG-2 was originally discovered as a pro-apoptotic protein in a genetic screen. Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. This review article discusses the current knowledge on the structure and potential function of this protein. Several putative binding partners of ALG-2 have been identified hinting to functions of ALG-2 in apoptosis and possibly also in proliferation, endocytosis and transcriptional regulation during development. Gene deletion of the well conserved ALG-2 locus in several genetic model organisms has so far not provided insights into functions and signaling pathways with ALG-2 involvement. Special focus is given to controversial data on expression and localization of ALG-2, which is mainly caused by the use of ALG-2 antibodies with different specificities.",

author = "Svetlana Tarabykina and Jens Mollerup and {Winding Gojkovic}, P. and Berchtold, {Martin Werner}",

year = "2004",

language = "English",

volume = "9",

pages = "1817--1832",

journal = "Frontiers in Bioscience",

issn = "1093-9946",

publisher = "Frontiers in Bioscience",

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TY - JOUR

T1 - ALG-2, a multifunctional calcium binding protein?

AU - Tarabykina, Svetlana

AU - Mollerup, Jens

AU - Winding Gojkovic, P.

AU - Berchtold, Martin Werner

PY - 2004

Y1 - 2004

N2 - ALG-2 was originally discovered as a pro-apoptotic protein in a genetic screen. Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. This review article discusses the current knowledge on the structure and potential function of this protein. Several putative binding partners of ALG-2 have been identified hinting to functions of ALG-2 in apoptosis and possibly also in proliferation, endocytosis and transcriptional regulation during development. Gene deletion of the well conserved ALG-2 locus in several genetic model organisms has so far not provided insights into functions and signaling pathways with ALG-2 involvement. Special focus is given to controversial data on expression and localization of ALG-2, which is mainly caused by the use of ALG-2 antibodies with different specificities.

AB - ALG-2 was originally discovered as a pro-apoptotic protein in a genetic screen. Due to its ability to bind calcium with high affinity it was postulated to provide a link between the known effect of calcium in programmed cell death and the molecular death execution machinery. This review article discusses the current knowledge on the structure and potential function of this protein. Several putative binding partners of ALG-2 have been identified hinting to functions of ALG-2 in apoptosis and possibly also in proliferation, endocytosis and transcriptional regulation during development. Gene deletion of the well conserved ALG-2 locus in several genetic model organisms has so far not provided insights into functions and signaling pathways with ALG-2 involvement. Special focus is given to controversial data on expression and localization of ALG-2, which is mainly caused by the use of ALG-2 antibodies with different specificities.

M3 - Journal article

SN - 1093-9946

VL - 9

SP - 1817

EP - 1832

JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

ER -