Alcohol, smoking and benign hepato-biliary disease

TY - JOUR

T1 - Alcohol, smoking and benign hepato-biliary disease

AU - Shabanzadeh, Daniel Mønsted

AU - Novovic, Srdan

PY - 2017/10

Y1 - 2017/10

N2 - Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers. Cholecystectomy is the preferred treatment for symptomatic gallstone disease. Studies about the impact of alcohol and smoking on the post-cholecystectomy state are few and future studies should be performed. Pancreatitis is associated with both excessive alcohol intake and smoking in observational studies. Interpretation of associations with pancreatitis is hampered by an incomplete understanding of underlying mechanisms and by the co-existence of excessive alcohol intake and smoking. Smoking cessation and alcohol abstinence is recommended in the treatment of pancreatitis, but higher-level evidence is needed.

AB - Gallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both alcohol intake and smoking do not alter the clinical course of gallstone disease carriers. Cholecystectomy is the preferred treatment for symptomatic gallstone disease. Studies about the impact of alcohol and smoking on the post-cholecystectomy state are few and future studies should be performed. Pancreatitis is associated with both excessive alcohol intake and smoking in observational studies. Interpretation of associations with pancreatitis is hampered by an incomplete understanding of underlying mechanisms and by the co-existence of excessive alcohol intake and smoking. Smoking cessation and alcohol abstinence is recommended in the treatment of pancreatitis, but higher-level evidence is needed.

KW - Alcohol drinking

KW - Alcohol-related disorders

KW - Alcoholic

KW - Alcoholism

KW - Cholecystectomy

KW - Cholelithiasis

KW - Chronic

KW - Gallbladder diseases

KW - Gallstones

KW - Laparoscopic

KW - Pancreatitis

KW - Smoking

U2 - 10.1016/j.bpg.2017.09.005

DO - 10.1016/j.bpg.2017.09.005

M3 - Review

C2 - 29195671

AN - SCOPUS:85029154929

SN - 1521-6918

VL - 31

SP - 519

EP - 527

JO - Bailliere's Best Practice and Research in Clinical Gastroenterology

JF - Bailliere's Best Practice and Research in Clinical Gastroenterology

IS - 5

ER -