Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

Konstantina Dimakopoulou; Evangelia Samoli; Rob Beelen; Massimo Stafoggia; Zorana Jovanovic Andersen; Barbara Hoffmann; Paul Fischer; Mark Nieuwenhuijsen; Paolo Vineis; Wei Xun; Gerard Hoek; Ole Raaschou-Nielsen; Anna Oudin; Bertil Forsberg; Lars Modig; Pekka Jousilahti; Timo Lanki; Anu Turunen; Bente Oftedal; Per Nafstad; Per E Schwarze; Johanna Penell; Laura Fratiglioni; Niklas Andersson; Nancy Pedersen; Michal Korek; Ulf De Faire; Kirsten Thorup Eriksen; Anne Tjønneland; Thomas Becker; Meng Wang; Bas Bueno-de-Mesquita; Ming-Yi Tsai; Marloes Eeftens; Petra H Peeters; Kees Meliefste; Alessandro Marcon; Ursula Krämer; Thomas Aj Kuhlbusch; Mohammad Vossoughi; Timothy Key; Kees de Hoogh; Regina Hampel; Annette Peters; Joachim Heinrich; Gudrun Weinmayr; Hans Concin; Gabriele Nagel; Alex Ineichen; Bénédicte Jacquemin; Morgane Stempfelet; Alice Vilier; Fulvio Ricceri; Carlotta Sacerdote; Xanthi Pedeli; Michalis Katsoulis; Antonia Trichopoulou; Bert Brunekreef; Klea Katsouyanni

doi:10.1164/rccm.201310-1777OC

Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

Konstantina Dimakopoulou, Evangelia Samoli, Rob Beelen, Massimo Stafoggia, Zorana Jovanovic Andersen, Barbara Hoffmann, Paul Fischer, Mark Nieuwenhuijsen, Paolo Vineis, Wei Xun, Gerard Hoek, Ole Raaschou-Nielsen, Anna Oudin, Bertil Forsberg, Lars Modig, Pekka Jousilahti, Timo Lanki, Anu Turunen, Bente Oftedal, Per NafstadPer E Schwarze, Johanna Penell, Laura Fratiglioni, Niklas Andersson, Nancy Pedersen, Michal Korek, Ulf De Faire, Kirsten Thorup Eriksen, Anne Tjønneland, Thomas Becker, Meng Wang, Bas Bueno-de-Mesquita, Ming-Yi Tsai, Marloes Eeftens, Petra H Peeters, Kees Meliefste, Alessandro Marcon, Ursula Krämer, Thomas Aj Kuhlbusch, Mohammad Vossoughi, Timothy Key, Kees de Hoogh, Regina Hampel, Annette Peters, Joachim Heinrich, Gudrun Weinmayr, Hans Concin, Gabriele Nagel, Alex Ineichen, Bénédicte Jacquemin, Morgane Stempfelet, Alice Vilier, Fulvio Ricceri, Carlotta Sacerdote, Xanthi Pedeli, Michalis Katsoulis, Antonia Trichopoulou, Bert Brunekreef, Klea Katsouyanni

52 Citationer (Scopus)

Abstract

Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.

Originalsprog	Engelsk
Tidsskrift	American Journal of Respiratory and Critical Care Medicine
Vol/bind	189
Udgave nummer	6
Sider (fra-til)	684-696
Antal sider	13
ISSN	1073-449X
DOI	https://doi.org/10.1164/rccm.201310-1777OC
Status	Udgivet - 15 mar. 2014

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Dimakopoulou, K., Samoli, E., Beelen, R., Stafoggia, M., Andersen, Z. J., Hoffmann, B., Fischer, P., Nieuwenhuijsen, M., Vineis, P., Xun, W., Hoek, G., Raaschou-Nielsen, O., Oudin, A., Forsberg, B., Modig, L., Jousilahti, P., Lanki, T., Turunen, A., Oftedal, B., ... Katsouyanni, K. (2014). Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project. American Journal of Respiratory and Critical Care Medicine, 189(6), 684-696. https://doi.org/10.1164/rccm.201310-1777OC

Dimakopoulou, K, Samoli, E, Beelen, R, Stafoggia, M, Andersen, ZJ, Hoffmann, B, Fischer, P, Nieuwenhuijsen, M, Vineis, P, Xun, W, Hoek, G, Raaschou-Nielsen, O, Oudin, A, Forsberg, B, Modig, L, Jousilahti, P, Lanki, T, Turunen, A, Oftedal, B, Nafstad, P, Schwarze, PE, Penell, J, Fratiglioni, L, Andersson, N, Pedersen, N, Korek, M, De Faire, U, Thorup Eriksen, K, Tjønneland, A, Becker, T, Wang, M, Bueno-de-Mesquita, B, Tsai, M-Y, Eeftens, M, Peeters, PH, Meliefste, K, Marcon, A, Krämer, U, Kuhlbusch, TA, Vossoughi, M, Key, T, de Hoogh, K, Hampel, R, Peters, A, Heinrich, J, Weinmayr, G, Concin, H, Nagel, G, Ineichen, A, Jacquemin, B, Stempfelet, M, Vilier, A, Ricceri, F, Sacerdote, C, Pedeli, X, Katsoulis, M, Trichopoulou, A, Brunekreef, B & Katsouyanni, K 2014, 'Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project', American Journal of Respiratory and Critical Care Medicine, bind 189, nr. 6, s. 684-696. https://doi.org/10.1164/rccm.201310-1777OC

@article{2be3be1ca9d04d64932157dcae6c7a05,

title = "Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project",

abstract = "Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.",

author = "Konstantina Dimakopoulou and Evangelia Samoli and Rob Beelen and Massimo Stafoggia and Andersen, {Zorana Jovanovic} and Barbara Hoffmann and Paul Fischer and Mark Nieuwenhuijsen and Paolo Vineis and Wei Xun and Gerard Hoek and Ole Raaschou-Nielsen and Anna Oudin and Bertil Forsberg and Lars Modig and Pekka Jousilahti and Timo Lanki and Anu Turunen and Bente Oftedal and Per Nafstad and Schwarze, {Per E} and Johanna Penell and Laura Fratiglioni and Niklas Andersson and Nancy Pedersen and Michal Korek and {De Faire}, Ulf and {Thorup Eriksen}, Kirsten and Anne Tj{\o}nneland and Thomas Becker and Meng Wang and Bas Bueno-de-Mesquita and Ming-Yi Tsai and Marloes Eeftens and Peeters, {Petra H} and Kees Meliefste and Alessandro Marcon and Ursula Kr{\"a}mer and Kuhlbusch, {Thomas Aj} and Mohammad Vossoughi and Timothy Key and {de Hoogh}, Kees and Regina Hampel and Annette Peters and Joachim Heinrich and Gudrun Weinmayr and Hans Concin and Gabriele Nagel and Alex Ineichen and B{\'e}n{\'e}dicte Jacquemin and Morgane Stempfelet and Alice Vilier and Fulvio Ricceri and Carlotta Sacerdote and Xanthi Pedeli and Michalis Katsoulis and Antonia Trichopoulou and Bert Brunekreef and Klea Katsouyanni",

year = "2014",

month = mar,

day = "15",

doi = "10.1164/rccm.201310-1777OC",

language = "English",

volume = "189",

pages = "684--696",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "6",

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TY - JOUR

T1 - Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

AU - Dimakopoulou, Konstantina

AU - Samoli, Evangelia

AU - Beelen, Rob

AU - Stafoggia, Massimo

AU - Andersen, Zorana Jovanovic

AU - Hoffmann, Barbara

AU - Fischer, Paul

AU - Nieuwenhuijsen, Mark

AU - Vineis, Paolo

AU - Xun, Wei

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Oudin, Anna

AU - Forsberg, Bertil

AU - Modig, Lars

AU - Jousilahti, Pekka

AU - Lanki, Timo

AU - Turunen, Anu

AU - Oftedal, Bente

AU - Nafstad, Per

AU - Schwarze, Per E

AU - Penell, Johanna

AU - Fratiglioni, Laura

AU - Andersson, Niklas

AU - Pedersen, Nancy

AU - Korek, Michal

AU - De Faire, Ulf

AU - Thorup Eriksen, Kirsten

AU - Tjønneland, Anne

AU - Becker, Thomas

AU - Wang, Meng

AU - Bueno-de-Mesquita, Bas

AU - Tsai, Ming-Yi

AU - Eeftens, Marloes

AU - Peeters, Petra H

AU - Meliefste, Kees

AU - Marcon, Alessandro

AU - Krämer, Ursula

AU - Kuhlbusch, Thomas Aj

AU - Vossoughi, Mohammad

AU - Key, Timothy

AU - de Hoogh, Kees

AU - Hampel, Regina

AU - Peters, Annette

AU - Heinrich, Joachim

AU - Weinmayr, Gudrun

AU - Concin, Hans

AU - Nagel, Gabriele

AU - Ineichen, Alex

AU - Jacquemin, Bénédicte

AU - Stempfelet, Morgane

AU - Vilier, Alice

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Pedeli, Xanthi

AU - Katsoulis, Michalis

AU - Trichopoulou, Antonia

AU - Brunekreef, Bert

AU - Katsouyanni, Klea

PY - 2014/3/15

Y1 - 2014/3/15

N2 - Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.

AB - Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratorymortality.

U2 - 10.1164/rccm.201310-1777OC

DO - 10.1164/rccm.201310-1777OC

M3 - Journal article

C2 - 24521254

SN - 1073-449X

VL - 189

SP - 684

EP - 696

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 6

ER -

Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

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