Age-specific differences between conventional and ambulatory daytime blood pressure values

David Conen; Stefanie Aeschbacher; Lutgarde Thijs; Yan Li; José Boggia; Kei Asayama; Tine W Hansen; Masahiro Kikuya; Kristina Björklund-Bodegård; Takayoshi Ohkubo; Jørgen Jeppesen; Yu-Mei Gu; Christian Torp-Pedersen; Eamon Dolan; Tatiana Kuznetsova; Katarzyna Stolarz-Skrzypek; Valérie Tikhonoff; Tobias Schoen; Sofia Malyutina; Edoardo Casiglia; Yuri Nikitin; Lars Lind; Edgardo Sandoya; Kalina Kawecka-Jaszcz; Luis Mena; Gladys E Maestre; Jan Filipovský; Yutaka Imai; Eoin O'Brien; Ji-Guang Wang; Lorenz Risch; Jan A Staessen

doi:10.1161/HYPERTENSIONAHA.114.03957

Age-specific differences between conventional and ambulatory daytime blood pressure values

David Conen, Stefanie Aeschbacher, Lutgarde Thijs, Yan Li, José Boggia, Kei Asayama, Tine W Hansen, Masahiro Kikuya, Kristina Björklund-Bodegård, Takayoshi Ohkubo, Jørgen Jeppesen, Yu-Mei Gu, Christian Torp-Pedersen, Eamon Dolan, Tatiana Kuznetsova, Katarzyna Stolarz-Skrzypek, Valérie Tikhonoff, Tobias Schoen, Sofia Malyutina, Edoardo CasigliaYuri Nikitin, Lars Lind, Edgardo Sandoya, Kalina Kawecka-Jaszcz, Luis Mena, Gladys E Maestre, Jan Filipovský, Yutaka Imai, Eoin O'Brien, Ji-Guang Wang, Lorenz Risch, Jan A Staessen

Institut for Klinisk Medicin

54 Citationer (Scopus)

Abstract

Mean daytime ambulatory blood pressure (BP) values are considered to be lower than conventional BP values, but data on this relation among younger individuals <50 years are scarce. Conventional and 24-hour ambulatory BP were measured in 9550 individuals not taking antihypertensive treatment from 13 population-based cohorts. We compared individual differences between daytime ambulatory and conventional BP according to 10-year age categories. Age-specific prevalences of white coat and masked hypertension were calculated. Among individuals aged 18 to 30, 30 to 40, and 40 to 50 years, mean daytime BP was significantly higher than the corresponding conventional BP (6.0, 5.2, and 4.7 mm Hg for systolic; 2.5, 2.7, and 1.7 mm Hg for diastolic BP; all P<0.0001). In individuals aged 60 to 70 and ≥70 years, conventional BP was significantly higher than daytime ambulatory BP (5.0 and 13.0 mm Hg for systolic; 2.0 and 4.2 mm Hg for diastolic BP; all P<0.0001).The prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18 to 30 years to those aged ≥70 years, with little variation between men and women (8.0% versus 6.1%; P=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%; P<0.0001). The age-specific prevalences of masked hypertension were 18.2%, 27.3%, 27.8%, 20.1%, 13.6%, and 10.2% among men and 9.0%, 9.9%, 12.2%, 11.9%, 14.7%, and 12.1% among women. In conclusion, this large collaborative analysis showed that the relation between daytime ambulatory and conventional BP strongly varies by age. These findings may have implications for diagnosing hypertension and its subtypes in clinical practice.

Originalsprog	Engelsk
Tidsskrift	Hypertension
Vol/bind	64
Udgave nummer	5
Sider (fra-til)	1073-1079
Antal sider	7
ISSN	0194-911X
DOI	https://doi.org/10.1161/HYPERTENSIONAHA.114.03957
Status	Udgivet - 1 nov. 2014

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10.1161/HYPERTENSIONAHA.114.03957

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Conen, D., Aeschbacher, S., Thijs, L., Li, Y., Boggia, J., Asayama, K., Hansen, T. W., Kikuya, M., Björklund-Bodegård, K., Ohkubo, T., Jeppesen, J., Gu, Y-M., Torp-Pedersen, C., Dolan, E., Kuznetsova, T., Stolarz-Skrzypek, K., Tikhonoff, V., Schoen, T., Malyutina, S., ... Staessen, J. A. (2014). Age-specific differences between conventional and ambulatory daytime blood pressure values. Hypertension, 64(5), 1073-1079. https://doi.org/10.1161/HYPERTENSIONAHA.114.03957

Conen, D, Aeschbacher, S, Thijs, L, Li, Y, Boggia, J, Asayama, K, Hansen, TW, Kikuya, M, Björklund-Bodegård, K, Ohkubo, T, Jeppesen, J, Gu, Y-M, Torp-Pedersen, C, Dolan, E, Kuznetsova, T, Stolarz-Skrzypek, K, Tikhonoff, V, Schoen, T, Malyutina, S, Casiglia, E, Nikitin, Y, Lind, L, Sandoya, E, Kawecka-Jaszcz, K, Mena, L, Maestre, GE, Filipovský, J, Imai, Y, O'Brien, E, Wang, J-G, Risch, L & Staessen, JA 2014, 'Age-specific differences between conventional and ambulatory daytime blood pressure values', Hypertension, bind 64, nr. 5, s. 1073-1079. https://doi.org/10.1161/HYPERTENSIONAHA.114.03957

@article{ef2f241b99344aa28bc5d3492a3f2556,

title = "Age-specific differences between conventional and ambulatory daytime blood pressure values",

abstract = "Mean daytime ambulatory blood pressure (BP) values are considered to be lower than conventional BP values, but data on this relation among younger individuals <50 years are scarce. Conventional and 24-hour ambulatory BP were measured in 9550 individuals not taking antihypertensive treatment from 13 population-based cohorts. We compared individual differences between daytime ambulatory and conventional BP according to 10-year age categories. Age-specific prevalences of white coat and masked hypertension were calculated. Among individuals aged 18 to 30, 30 to 40, and 40 to 50 years, mean daytime BP was significantly higher than the corresponding conventional BP (6.0, 5.2, and 4.7 mm Hg for systolic; 2.5, 2.7, and 1.7 mm Hg for diastolic BP; all P<0.0001). In individuals aged 60 to 70 and ≥70 years, conventional BP was significantly higher than daytime ambulatory BP (5.0 and 13.0 mm Hg for systolic; 2.0 and 4.2 mm Hg for diastolic BP; all P<0.0001).The prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18 to 30 years to those aged ≥70 years, with little variation between men and women (8.0% versus 6.1%; P=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%; P<0.0001). The age-specific prevalences of masked hypertension were 18.2%, 27.3%, 27.8%, 20.1%, 13.6%, and 10.2% among men and 9.0%, 9.9%, 12.2%, 11.9%, 14.7%, and 12.1% among women. In conclusion, this large collaborative analysis showed that the relation between daytime ambulatory and conventional BP strongly varies by age. These findings may have implications for diagnosing hypertension and its subtypes in clinical practice.",

keywords = "Adolescent, Adult, Aging, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Masked Hypertension, Middle Aged, Office Visits, Prevalence, White Coat Hypertension, Young Adult",

author = "David Conen and Stefanie Aeschbacher and Lutgarde Thijs and Yan Li and Jos{\'e} Boggia and Kei Asayama and Hansen, {Tine W} and Masahiro Kikuya and Kristina Bj{\"o}rklund-Bodeg{\aa}rd and Takayoshi Ohkubo and J{\o}rgen Jeppesen and Yu-Mei Gu and Christian Torp-Pedersen and Eamon Dolan and Tatiana Kuznetsova and Katarzyna Stolarz-Skrzypek and Val{\'e}rie Tikhonoff and Tobias Schoen and Sofia Malyutina and Edoardo Casiglia and Yuri Nikitin and Lars Lind and Edgardo Sandoya and Kalina Kawecka-Jaszcz and Luis Mena and Maestre, {Gladys E} and Jan Filipovsk{\'y} and Yutaka Imai and Eoin O'Brien and Ji-Guang Wang and Lorenz Risch and Staessen, {Jan A}",

note = "{\textcopyright} 2014 American Heart Association, Inc.",

year = "2014",

month = nov,

day = "1",

doi = "10.1161/HYPERTENSIONAHA.114.03957",

language = "English",

volume = "64",

pages = "1073--1079",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams & Wilkins",

number = "5",

}

TY - JOUR

T1 - Age-specific differences between conventional and ambulatory daytime blood pressure values

AU - Conen, David

AU - Aeschbacher, Stefanie

AU - Thijs, Lutgarde

AU - Li, Yan

AU - Boggia, José

AU - Asayama, Kei

AU - Hansen, Tine W

AU - Kikuya, Masahiro

AU - Björklund-Bodegård, Kristina

AU - Ohkubo, Takayoshi

AU - Jeppesen, Jørgen

AU - Gu, Yu-Mei

AU - Torp-Pedersen, Christian

AU - Dolan, Eamon

AU - Kuznetsova, Tatiana

AU - Stolarz-Skrzypek, Katarzyna

AU - Tikhonoff, Valérie

AU - Schoen, Tobias

AU - Malyutina, Sofia

AU - Casiglia, Edoardo

AU - Nikitin, Yuri

AU - Lind, Lars

AU - Sandoya, Edgardo

AU - Kawecka-Jaszcz, Kalina

AU - Mena, Luis

AU - Maestre, Gladys E

AU - Filipovský, Jan

AU - Imai, Yutaka

AU - O'Brien, Eoin

AU - Wang, Ji-Guang

AU - Risch, Lorenz

AU - Staessen, Jan A

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Mean daytime ambulatory blood pressure (BP) values are considered to be lower than conventional BP values, but data on this relation among younger individuals <50 years are scarce. Conventional and 24-hour ambulatory BP were measured in 9550 individuals not taking antihypertensive treatment from 13 population-based cohorts. We compared individual differences between daytime ambulatory and conventional BP according to 10-year age categories. Age-specific prevalences of white coat and masked hypertension were calculated. Among individuals aged 18 to 30, 30 to 40, and 40 to 50 years, mean daytime BP was significantly higher than the corresponding conventional BP (6.0, 5.2, and 4.7 mm Hg for systolic; 2.5, 2.7, and 1.7 mm Hg for diastolic BP; all P<0.0001). In individuals aged 60 to 70 and ≥70 years, conventional BP was significantly higher than daytime ambulatory BP (5.0 and 13.0 mm Hg for systolic; 2.0 and 4.2 mm Hg for diastolic BP; all P<0.0001).The prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18 to 30 years to those aged ≥70 years, with little variation between men and women (8.0% versus 6.1%; P=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%; P<0.0001). The age-specific prevalences of masked hypertension were 18.2%, 27.3%, 27.8%, 20.1%, 13.6%, and 10.2% among men and 9.0%, 9.9%, 12.2%, 11.9%, 14.7%, and 12.1% among women. In conclusion, this large collaborative analysis showed that the relation between daytime ambulatory and conventional BP strongly varies by age. These findings may have implications for diagnosing hypertension and its subtypes in clinical practice.

AB - Mean daytime ambulatory blood pressure (BP) values are considered to be lower than conventional BP values, but data on this relation among younger individuals <50 years are scarce. Conventional and 24-hour ambulatory BP were measured in 9550 individuals not taking antihypertensive treatment from 13 population-based cohorts. We compared individual differences between daytime ambulatory and conventional BP according to 10-year age categories. Age-specific prevalences of white coat and masked hypertension were calculated. Among individuals aged 18 to 30, 30 to 40, and 40 to 50 years, mean daytime BP was significantly higher than the corresponding conventional BP (6.0, 5.2, and 4.7 mm Hg for systolic; 2.5, 2.7, and 1.7 mm Hg for diastolic BP; all P<0.0001). In individuals aged 60 to 70 and ≥70 years, conventional BP was significantly higher than daytime ambulatory BP (5.0 and 13.0 mm Hg for systolic; 2.0 and 4.2 mm Hg for diastolic BP; all P<0.0001).The prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18 to 30 years to those aged ≥70 years, with little variation between men and women (8.0% versus 6.1%; P=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%; P<0.0001). The age-specific prevalences of masked hypertension were 18.2%, 27.3%, 27.8%, 20.1%, 13.6%, and 10.2% among men and 9.0%, 9.9%, 12.2%, 11.9%, 14.7%, and 12.1% among women. In conclusion, this large collaborative analysis showed that the relation between daytime ambulatory and conventional BP strongly varies by age. These findings may have implications for diagnosing hypertension and its subtypes in clinical practice.

KW - Adolescent

KW - Adult

KW - Aging

KW - Blood Pressure

KW - Blood Pressure Monitoring, Ambulatory

KW - Circadian Rhythm

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Male

KW - Masked Hypertension

KW - Middle Aged

KW - Office Visits

KW - Prevalence

KW - White Coat Hypertension

KW - Young Adult

U2 - 10.1161/HYPERTENSIONAHA.114.03957

DO - 10.1161/HYPERTENSIONAHA.114.03957

M3 - Journal article

C2 - 25185130

SN - 0194-911X

VL - 64

SP - 1073

EP - 1079

JO - Hypertension

JF - Hypertension

IS - 5

ER -

Age-specific differences between conventional and ambulatory daytime blood pressure values

Abstract

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