Age-period-cohort modelling of breast cancer incidence in the Nordic countries.

TY - JOUR

T1 - Age-period-cohort modelling of breast cancer incidence in the Nordic countries.

AU - Rostgaard, K

AU - Vaeth, M

AU - Holst, H

AU - Madsen, Mette

AU - Lynge, E

N1 - Keywords: Adult; Age Factors; Aged; Aged, 80 and over; Breast Neoplasms; Cohort Effect; Cohort Studies; Epidemiologic Factors; Female; Finland; Humans; Incidence; Linear Models; Mammography; Mass Screening; Middle Aged; Models, Statistical; Risk Factors; Scandinavia

PY - 2001

Y1 - 2001

N2 - The Nordic countries have experienced a steady increase in breast cancer incidence throughout the past 35 years. We analysed the incidence in Denmark, Finland, Norway and Sweden during the period 1958 to 1992 using age-period-cohort models and taking the systematic mammography screening into account. Assuming the age dependency of the incidence pattern in old age to be common for the Nordic countries, an internal comparison could be made among the four countries of the cohort effects and the period effects. The study indicated that the period effects have been of importance for the increase in breast cancer incidence seen in the Nordic countries. The widespread practice of neglecting the period effects in age-period-cohort analysis of time trends in breast cancer incidence therefore probably needs reconsideration. A key finding was that Danish women born in the 20th century seem to have been exposed to an increasing load of cohort borne breast cancer risk factors not experienced to the same extent by Norwegian women, whereas they were seemingly subjected to the same period effects.

AB - The Nordic countries have experienced a steady increase in breast cancer incidence throughout the past 35 years. We analysed the incidence in Denmark, Finland, Norway and Sweden during the period 1958 to 1992 using age-period-cohort models and taking the systematic mammography screening into account. Assuming the age dependency of the incidence pattern in old age to be common for the Nordic countries, an internal comparison could be made among the four countries of the cohort effects and the period effects. The study indicated that the period effects have been of importance for the increase in breast cancer incidence seen in the Nordic countries. The widespread practice of neglecting the period effects in age-period-cohort analysis of time trends in breast cancer incidence therefore probably needs reconsideration. A key finding was that Danish women born in the 20th century seem to have been exposed to an increasing load of cohort borne breast cancer risk factors not experienced to the same extent by Norwegian women, whereas they were seemingly subjected to the same period effects.

KW - Faculty of Health and Medical Sciences

KW - Adult

KW - Age Factors

KW - Aged

KW - Breast Neoplasms

KW - Cohort Effect

KW - Cohort Studies

KW - Epidemiologic Factors

KW - Female

KW - Finland

KW - Humans

KW - Incidence

KW - Linear Models

KW - Mammography

KW - Mass Screening

KW - Middle Aged

KW - Models

KW - Statistical

KW - Risk Factors

KW - Scandinavia

M3 - Journal article

C2 - 11135347

SN - 0277-6715

VL - 20

SP - 47

EP - 61

JO - Statistics in Medicine

JF - Statistics in Medicine

IS - 1

ER -