Abstract
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 10168 |
| Tidsskrift | Scientific Reports |
| Vol/bind | 8 |
| Udgave nummer | 1 |
| Sider (fra-til) | 1-14 |
| ISSN | 2045-2322 |
| DOI | |
| Status | Udgivet - 2018 |
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Age at first birth in women is genetically associated with increased risk of schizophrenia. / Ni, Guiyan; Gratten, Jacob; Wray, Naomi R. et al.
I: Scientific Reports, Bind 8, Nr. 1, 10168, 2018, s. 1-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Age at first birth in women is genetically associated with increased risk of schizophrenia
AU - Ni, Guiyan
AU - Gratten, Jacob
AU - Wray, Naomi R.
AU - Lee, Sang Hong
AU - Ripke, Stephan
AU - Neale, Benjamin M.
AU - Corvin, Aiden
AU - Walters, James T.R.
AU - Farh, Kai How
AU - Holmans, Peter A.
AU - Lee, Phil
AU - Bulik-Sullivan, Brendan
AU - Collier, David A.
AU - Huang, Hailiang
AU - Pers, Tune H.
AU - Agartz, Ingrid
AU - Agerbo, Esben
AU - Albus, Margot
AU - Alexander, Madeline
AU - Amin, Farooq
AU - Bacanu, Silviu A.
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AU - Belliveau, Richard A.
AU - Bene, Judit
AU - Bergen, Sarah E.
AU - Bevilacqua, Elizabeth
AU - Bigdeli, Tim B.
AU - Black, Donald W.
AU - Bruggeman, Richard
AU - Buccola, Nancy G.
AU - Buckner, Randy L.
AU - Byerley, William
AU - Cahn, Wiepke
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AU - Campion, Dominique
AU - Cantor, Rita M.
AU - Carr, Vaughan J.
AU - Carrera, Noa
AU - Catts, Stanley V.
AU - Chambert, Kimberly D.
AU - Chan, Raymond C.K.
AU - Chen, Ronald Y.L.
AU - Chen, Eric Y.H.
AU - Cheng, Wei
AU - Cheung, Eric F.C.
AU - Chong, Siow Ann
AU - Cloninger, C. Robert
AU - Cohen, David
AU - Cohen, Nadine
AU - Cormican, Paul
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AU - Crowley, James J.
AU - Curtis, David
AU - Davidson, Michael
AU - Davis, Kenneth L.
AU - Degenhardt, Franziska
AU - Del Favero, Jurgen
AU - Demontis, Ditte
AU - Dikeos, Dimitris
AU - Dinan, Timothy
AU - Djurovic, Srdjan
AU - Donohoe, Gary
AU - Drapeau, Elodie
AU - Duan, Jubao
AU - Dudbridge, Frank
AU - Durmishi, Naser
AU - Eichhammer, Peter
AU - Eriksson, Johan
AU - Escott-Price, Valentina
AU - Essioux, Laurent
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AU - Farrell, Martilias S.
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AU - Georgieva, Lyudmila
AU - Giegling, Ina
AU - Giusti-Rodríguez, Paola
AU - Godard, Stephanie
AU - Goldstein, Jacqueline I.
AU - Golimbet, Vera
AU - Gopal, Srihari
AU - Haan, Lieuwe De
AU - Hammer, Christian
AU - Hamshere, Marian L.
AU - Hansen, Mark
AU - Hansen, Thomas
AU - Haroutunian, Vahram
AU - Hartmann, Annette M.
AU - Henskens, Frans A.
AU - Herms, Stefan
AU - Hirschhorn, Joel N.
AU - Hoffmann, Per
AU - Hofman, Andrea
AU - Hollegaard, Mads V.
AU - Hougaard, David M.
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AU - Joa, Inge
AU - Juliá, Antonio
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AU - Klovins, Janis
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AU - Konte, Bettina
AU - Kucinskas, Vaidutis
AU - Kucinskiene, Zita Ausrele
AU - Kuzelova-Ptackova, Hana
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AU - Laurent, Claudine
AU - Keong, Jimmy Lee Chee
AU - Legge, Sophie E.
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AU - Li, Miaoxin
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AU - Lieberman, Jeffrey
AU - Limborska, Svetlana
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AU - Lubinski, Jan
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AU - Macek, Milan
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AU - Mattheisen, Manuel
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AU - Meijer, Carin J.
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AU - Michie, Patricia T.
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AU - Nisenbaum, Laura
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AU - O'dushlaine, Colm
AU - O'neill, F. Anthony
AU - Oh, Sang Yun
AU - Olincy, Ann
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AU - Os, Jim Van
AU - Pantelis, Christos
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AU - Perkins, Diana O.
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AU - Stroup, T. Scott
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AU - Söderman, Erik
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AU - Zheng, Xuebin
AU - Zimprich, Fritz
AU - Stefansson, Kari
AU - Visscher, Peter M.
AU - Adolfsson, Rolf
AU - Andreassen, Ole A.
AU - Blackwood, Douglas H.R.
AU - Bramon, Elvira
AU - Buxbaum, Joseph D.
AU - Børglum, Anders D.
AU - Cichon, Sven
AU - Darvasi, Ariel
AU - Domenici, Enrico
AU - Ehrenreich, Hannelore
AU - Esko, Tõnu
AU - Gejman, Pablo V.
AU - Gill, Michael
AU - Gurling, Hugh
AU - Hultman, Christina M.
AU - Iwata, Nakao
AU - Jablensky, Assen V.
AU - Jönsson, Erik G.
AU - Kendler, Kenneth S.
AU - Kirov, George
AU - Knight, Jo
AU - Lencz, Todd
AU - Levinson, Douglas F.
AU - Li, Qingqin S.
AU - Liu, Jianjun
AU - Malhotra, Anil K.
AU - McCarroll, Steven A.
AU - McQuillin, Andrew
AU - Moran, Jennifer L.
AU - Mortensen, Preben B.
AU - Mowry, Bryan J.
AU - Nöthen, Markus M.
AU - Ophoff, Roel A.
AU - Owen, Michael J.
AU - Palotie, Aarno
AU - Pato, Carlos N.
AU - Petryshen, Tracey L.
AU - Posthuma, Danielle
AU - Rietschel, Marcella
AU - Riley, Brien P.
AU - Rujescu, Dan
AU - Sham, Pak C.
AU - Sklar, Pamela
AU - Clair, David St
AU - Weinberger, Daniel R.
AU - Wendland, Jens R.
AU - Werge, Thomas
AU - Daly, Mark J.
AU - Sullivan, Patrick F.
AU - O'donovan, Michael C.
PY - 2018
Y1 - 2018
N2 - Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
AB - Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.
U2 - 10.1038/s41598-018-28160-z
DO - 10.1038/s41598-018-28160-z
M3 - Journal article
C2 - 29977057
AN - SCOPUS:85049684948
SN - 2045-2322
VL - 8
SP - 1
EP - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 10168
ER -