Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial

Bernhard Franzke; Barbara Schober-Halper; Marlene Hofmann; Stefan Oesen; Anela Tosevska; Trine Henriksen; Henrik E. Poulsen; Eva Maria Strasser; Barbara Wessner; Karl Heinz Wagner

doi:10.1016/j.freeradbiomed.2018.04.565

Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial

Bernhard Franzke^*, Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Anela Tosevska, Trine Henriksen, Henrik E. Poulsen, Eva Maria Strasser, Barbara Wessner, Karl Heinz Wagner

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n = 117, age = 83.1 ± 6.1 years) – resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) – performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an “antioxidant factor” to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests. We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = −0.350, p = 0.001), and between high sensitive troponin-T and the 6-min-walking test (r = −0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over LE, subjects of the RT group demonstrated a significant greater response in the “antioxidant factor” compared to RTS and CT (RT vs. RTS p = 0.033, RT vs. CT p = 0.028), whereas no difference was observed between the intervention groups under LE. Six months of elastic band resistance training lead to improvements in antioxidant defense, DNA stability and oxidative damage, summarized in the “antioxidant factor”, however mainly in subjects over their statistical LE. Consuming a supplement containing antioxidants might inhibit optimal cellular response to exercise. The study was approved by the ethics committee of the City of Vienna (EK-11–151–0811) and registered at ClinicalTrials.gov, NCT01775111.

Originalsprog	Engelsk
Tidsskrift	Free Radical Biology and Medicine
Vol/bind	121
Sider (fra-til)	69-77
Antal sider	9
ISSN	0891-5849
DOI	https://doi.org/10.1016/j.freeradbiomed.2018.04.565
Status	Udgivet - 2018

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10.1016/j.freeradbiomed.2018.04.565

Citationsformater

Franzke, B., Schober-Halper, B., Hofmann, M., Oesen, S., Tosevska, A., Henriksen, T., Poulsen, H. E., Strasser, E. M., Wessner, B., & Wagner, K. H. (2018). Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial. Free Radical Biology and Medicine, 121, 69-77. https://doi.org/10.1016/j.freeradbiomed.2018.04.565

Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial. / Franzke, Bernhard; Schober-Halper, Barbara; Hofmann, Marlene et al.

I: Free Radical Biology and Medicine, Bind 121, 2018, s. 69-77.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Franzke, B, Schober-Halper, B, Hofmann, M, Oesen, S, Tosevska, A, Henriksen, T, Poulsen, HE, Strasser, EM, Wessner, B & Wagner, KH 2018, 'Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial', Free Radical Biology and Medicine, bind 121, s. 69-77. https://doi.org/10.1016/j.freeradbiomed.2018.04.565

@article{24b927e6382a45749f9902688d3ac7d1,

title = "Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial",

abstract = "The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n = 117, age = 83.1 ± 6.1 years) – resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) – performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an “antioxidant factor” to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests. We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = −0.350, p = 0.001), and between high sensitive troponin-T and the 6-min-walking test (r = −0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over LE, subjects of the RT group demonstrated a significant greater response in the “antioxidant factor” compared to RTS and CT (RT vs. RTS p = 0.033, RT vs. CT p = 0.028), whereas no difference was observed between the intervention groups under LE. Six months of elastic band resistance training lead to improvements in antioxidant defense, DNA stability and oxidative damage, summarized in the “antioxidant factor”, however mainly in subjects over their statistical LE. Consuming a supplement containing antioxidants might inhibit optimal cellular response to exercise. The study was approved by the ethics committee of the City of Vienna (EK-11–151–0811) and registered at ClinicalTrials.gov, NCT01775111.",

keywords = "Aging, Antioxidants, DNA damage, Elderly, Exercise, Life-expectancy, Lifestyle, Oxidative stress, Resistance training, Vitamins",

author = "Bernhard Franzke and Barbara Schober-Halper and Marlene Hofmann and Stefan Oesen and Anela Tosevska and Trine Henriksen and Poulsen, {Henrik E.} and Strasser, {Eva Maria} and Barbara Wessner and Wagner, {Karl Heinz}",

year = "2018",

doi = "10.1016/j.freeradbiomed.2018.04.565",

language = "English",

volume = "121",

pages = "69--77",

journal = "Free Radical Biology & Medicine",

issn = "0891-5849",

publisher = "Elsevier",

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TY - JOUR

T1 - Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial

AU - Franzke, Bernhard

AU - Schober-Halper, Barbara

AU - Hofmann, Marlene

AU - Oesen, Stefan

AU - Tosevska, Anela

AU - Henriksen, Trine

AU - Poulsen, Henrik E.

AU - Strasser, Eva Maria

AU - Wessner, Barbara

AU - Wagner, Karl Heinz

PY - 2018

Y1 - 2018

N2 - The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n = 117, age = 83.1 ± 6.1 years) – resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) – performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an “antioxidant factor” to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests. We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = −0.350, p = 0.001), and between high sensitive troponin-T and the 6-min-walking test (r = −0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over LE, subjects of the RT group demonstrated a significant greater response in the “antioxidant factor” compared to RTS and CT (RT vs. RTS p = 0.033, RT vs. CT p = 0.028), whereas no difference was observed between the intervention groups under LE. Six months of elastic band resistance training lead to improvements in antioxidant defense, DNA stability and oxidative damage, summarized in the “antioxidant factor”, however mainly in subjects over their statistical LE. Consuming a supplement containing antioxidants might inhibit optimal cellular response to exercise. The study was approved by the ethics committee of the City of Vienna (EK-11–151–0811) and registered at ClinicalTrials.gov, NCT01775111.

AB - The purpose of this study was to investigated the effect of age – over or under life-expectancy (LE) – on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n = 117, age = 83.1 ± 6.1 years) – resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) – performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an “antioxidant factor” to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests. We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = −0.350, p = 0.001), and between high sensitive troponin-T and the 6-min-walking test (r = −0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over LE, subjects of the RT group demonstrated a significant greater response in the “antioxidant factor” compared to RTS and CT (RT vs. RTS p = 0.033, RT vs. CT p = 0.028), whereas no difference was observed between the intervention groups under LE. Six months of elastic band resistance training lead to improvements in antioxidant defense, DNA stability and oxidative damage, summarized in the “antioxidant factor”, however mainly in subjects over their statistical LE. Consuming a supplement containing antioxidants might inhibit optimal cellular response to exercise. The study was approved by the ethics committee of the City of Vienna (EK-11–151–0811) and registered at ClinicalTrials.gov, NCT01775111.

KW - Aging

KW - Antioxidants

KW - DNA damage

KW - Elderly

KW - Exercise

KW - Life-expectancy

KW - Lifestyle

KW - Oxidative stress

KW - Resistance training

KW - Vitamins

U2 - 10.1016/j.freeradbiomed.2018.04.565

DO - 10.1016/j.freeradbiomed.2018.04.565

M3 - Journal article

C2 - 29698742

AN - SCOPUS:85046657470

SN - 0891-5849

VL - 121

SP - 69

EP - 77

JO - Free Radical Biology & Medicine

JF - Free Radical Biology & Medicine

ER -

Age and the effect of exercise, nutrition and cognitive training on oxidative stress – The Vienna Active Aging Study (VAAS), a randomized controlled trial

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