TY - JOUR
T1 - Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta
AU - Eriksen, Nina
AU - Stark, Anette Kirstine
AU - Pakkenberg, Bente
N1 - Keywords: Aging; Animals; Cell Death; Dopamine; Humans; Neurons; Parkinson Disease; Substantia Nigra; alpha-Synuclein
PY - 2009
Y1 - 2009
N2 - During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.
AB - During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.
M3 - Journal article
C2 - 20411779
SN - 0303-6995
SP - 203
EP - 213
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
IS - 73
ER -