Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X: A pilot study

TY - JOUR

T1 - Aerobic anti-gravity exercise in patients with Charcot-Marie-Tooth disease types 1A and X

T2 - A pilot study

AU - Knak, Kirsten L

AU - Andersen, Linda K

AU - Vissing, John

PY - 2017/12

Y1 - 2017/12

N2 - Background: Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit.Aim: The aim was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X.Methods: Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks.Results: There was a significant positive difference in Berg balance scale and postural stability test between test occasions, and walking distance in the 6-min walk test trended to increase.Conclusions: The study indicates that the anti-gravity treadmill training of patients with CMT should be pursued in larger CMT cohorts.

AB - Background: Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy associated with impaired walking capacity. Some patients are too weak in the lower extremity muscles to walk at gravity with sufficient intensity or duration to gain benefit.Aim: The aim was to investigate the effect of aerobic anti-gravity exercise in weak patients with CMT 1A and X.Methods: Five adult patients performed moderate-intensity aerobic anti-gravity exercise 3/week for 10 weeks.Results: There was a significant positive difference in Berg balance scale and postural stability test between test occasions, and walking distance in the 6-min walk test trended to increase.Conclusions: The study indicates that the anti-gravity treadmill training of patients with CMT should be pursued in larger CMT cohorts.

U2 - 10.1002/brb3.794

DO - 10.1002/brb3.794

M3 - Journal article

C2 - 29299376

SN - 2162-3279

VL - 7

JO - Brain and Behavior

JF - Brain and Behavior

IS - 12

M1 - e00794

ER -