@article{911a86c0acd111ddb538000ea68e967b,
title = "Adverse pregnancy outcomes in offspring of fathers working in biomedical research laboratories.",
abstract = "BACKGROUND: Laboratory work may constitute a possible health hazard for workers as well as for their offspring, and involves a wide range of exposures, such as organic solvents, carcinogenic agents, ionizing radiation, and/or microbiological agents. Adverse pregnancy outcomes in the offspring of male employees in biomedical research laboratories are examined. METHODS: Offspring to males employed 1970-1989 at four Swedish universities were identified via the Medical Birth Register (MBR), along with other pregnancy parameters. Offspring of fathers with laboratory work (n = 2,281) is considered exposed, and of non-laboratory employees unexposed (n = 1,909). Exposure data were obtained by questionnaires to research group leaders. Logistic regression analysis estimated odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Paternal laboratory work in general showed no statistically significant increased ORs concerning birth weight and/or gestational age, but work specifically with radioactive isotopes gave OR 1.8 (CI 1.0-3.2) for high birth weight and a relative risk of 1.2 (CI 1.0-1.4) for sex ratio (male/female). CONCLUSIONS: There was no clear association between periconceptional paternal laboratory work and adverse reproductive outcomes, but use of radioactive isotopes showed increased OR for high birth weight in offspring.",
author = "Magnusson, {Linda L} and Lennart Bodin and Helena Wennborg",
note = "Keywords: Adult; Biomedical Technology; Birth Weight; Female; Humans; Laboratories; Logistic Models; Male; Occupational Exposure; Odds Ratio; Paternal Exposure; Questionnaires; Radioisotopes; Registries; Solvents; Sweden",
year = "2006",
doi = "10.1002/ajim.20317",
language = "English",
volume = "49",
pages = "468--73",
journal = "American Journal of Industrial Medicine",
issn = "0271-3586",
publisher = "JohnWiley & Sons, Inc.",
number = "6",
}