@article{162bade0b31511debc73000ea68e967b,
title = "Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa.",
abstract = "L-Dopa is metabolized to 3-O-methyldopa (3OMD) by catechol-O-methyltransferase (COMT). This reduces the amount of L-dopa available for entry into brain. We studied the effect of OR-611, a new COMT inhibitor, on plasma and brain 6-[18F]-fluoro-L-dopa (6FD) metabolism in cynomolgus monkeys with positron emission tomography (PET). OR-611 pretreatment substantially reduced plasma 6FD metabolism to 3-O-methylfluorodopa (3OMFD). PET measurements of striatal 6FD concentrations showed an average 2.3-fold increase following OR-611 pretreatment, compared to the same animals in the control state. OR-611 inhibits plasma metabolism of 6FD and increases brain uptake of this L-dopa analog. OR-611 appears to be a promising agent as an adjunct to L-dopa for the treatment of patients with Parkinson's disease.",
author = "M Guttman and G L{\'e}ger and A Reches and A Evans and H Kuwabara and Cedarbaum, {J M} and A Gjedde",
year = "1993",
doi = "10.1002/mds.870080308",
language = "English",
volume = "8",
pages = "298--304",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "JohnWiley & Sons, Inc.",
number = "3",
}