Adenosine triphosphatases of thermophilic archaeal double-stranded DNA viruses

TY - JOUR

T1 - Adenosine triphosphatases of thermophilic archaeal double-stranded DNA viruses

AU - Happonen, Lotta J.

AU - Erdmann, Susanne

AU - Garrett, Roger Antony

AU - Butcher, Sarah J

PY - 2014/7/23

Y1 - 2014/7/23

N2 - Adenosine triphosphatases (ATPases) of double-stranded (ds) DNA archaeal viruses are structurally related to the AAA+ hexameric helicases and translocases. These ATPases have been implicated in viral life cycle functions such as DNA entry into the host, and viral genome packaging into preformed procapsids. We summarize bioinformatical analyses of a wide range of archaeal ATPases, and review the biochemical and structural properties of those archaeal ATPases that have measurable ATPase activity. We discuss their potential roles in genome delivery into the host, virus assembly and genome packaging in comparison to hexameric helicases and packaging motors from bacteriophages.

AB - Adenosine triphosphatases (ATPases) of double-stranded (ds) DNA archaeal viruses are structurally related to the AAA+ hexameric helicases and translocases. These ATPases have been implicated in viral life cycle functions such as DNA entry into the host, and viral genome packaging into preformed procapsids. We summarize bioinformatical analyses of a wide range of archaeal ATPases, and review the biochemical and structural properties of those archaeal ATPases that have measurable ATPase activity. We discuss their potential roles in genome delivery into the host, virus assembly and genome packaging in comparison to hexameric helicases and packaging motors from bacteriophages.

U2 - 10.1186/2045-3701-4-37

DO - 10.1186/2045-3701-4-37

M3 - Review

C2 - 25105011

SN - 2045-3701

VL - 4

SP - 37

EP - 52

JO - Cell and Bioscience

JF - Cell and Bioscience

IS - 37

ER -