TY - JOUR
T1 - Additional targets of the Arabidopsis autonomous pathway members, FCA and FY
AU - Marquardt, Sebastian
AU - Boss, P.K.
AU - Hadfield, J.
AU - Dean, C.
PY - 2006
Y1 - 2006
N2 - A central player in the Arabidopsis floral transition is the floral repressor FLC, the MADS-box transcriptional regulator that inhibits the activity of genes required to switch the meristem from vegetative to floral development. One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK. Rather than a hierarchical set of activities the autonomous promotion pathway comprises sub-pathways of genes with different biochemical functions that all share FLC as a target. One sub-pathway involves FCA and FY, which interact to regulate RNA processing of FLC. Several of the identified components (FY, FVE, and FLD) are homologous to yeast and mammalian proteins with rather generic roles in gene regulation. So why do mutations in these genes specifically show a late-flowering phenotype in Arabidopsis? One reason, found during the analysis of fy alleles, is that the mutant alleles identified in flowering screens can be hypomorphic, they still have partial function. A broader role for the autonomous promotion pathway is supported by a microarray analysis which has identified genes mis-regulated in fca mutants, and whose expression is also altered in fy mutants.
AB - A central player in the Arabidopsis floral transition is the floral repressor FLC, the MADS-box transcriptional regulator that inhibits the activity of genes required to switch the meristem from vegetative to floral development. One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK. Rather than a hierarchical set of activities the autonomous promotion pathway comprises sub-pathways of genes with different biochemical functions that all share FLC as a target. One sub-pathway involves FCA and FY, which interact to regulate RNA processing of FLC. Several of the identified components (FY, FVE, and FLD) are homologous to yeast and mammalian proteins with rather generic roles in gene regulation. So why do mutations in these genes specifically show a late-flowering phenotype in Arabidopsis? One reason, found during the analysis of fy alleles, is that the mutant alleles identified in flowering screens can be hypomorphic, they still have partial function. A broader role for the autonomous promotion pathway is supported by a microarray analysis which has identified genes mis-regulated in fca mutants, and whose expression is also altered in fy mutants.
KW - Alleles
KW - Arabidopsis
KW - Arabidopsis Proteins
KW - Flowers
KW - Gene Expression Regulation, Plant
KW - Models, Genetic
KW - Mutation
KW - Oligonucleotide Array Sequence Analysis
KW - Polyadenylation
KW - RNA Processing, Post-Transcriptional
KW - RNA, Messenger
KW - RNA-Binding Proteins
KW - mRNA Cleavage and Polyadenylation Factors
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1093/jxb/erl073
DO - 10.1093/jxb/erl073
M3 - Review
C2 - 16940039
SN - 0022-0957
VL - 57
SP - 3379
EP - 3386
JO - Journal of Experimental Botany. Flowering Newsletter
JF - Journal of Experimental Botany. Flowering Newsletter
IS - 13
ER -