Adaptive diversity of innate immune receptor family short pentraxins in Murinae

Yan Li; Judith H Robins; Jianping Ye; Zhiyong Huang; Qiang Wen; Guojie Zhang

doi:10.1016/j.febslet.2012.01.048

Adaptive diversity of innate immune receptor family short pentraxins in Murinae

Yan Li, Judith H Robins, Jianping Ye, Zhiyong Huang, Qiang Wen, Guojie Zhang

2 Citationer (Scopus)

Abstract

The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we examined the evolution of short pentraxins in Murinae lineages. By molecular evolutionary analysis, CRP and SAP have been experiencing rapid diversification, driven by adaptive selection. Further, our protein modeling demonstrates that adaptively selected amino acids lie in the ligand-binding region and contact region between subunits. Our findings suggest that rapid diversification of these regions could contribute to the determinants of recognizing specificity and the interaction between subunits.

Originalsprog	Engelsk
Tidsskrift	F E B S Letters
Vol/bind	586
Udgave nummer	6
Sider (fra-til)	798-803
Antal sider	6
ISSN	0014-5793
DOI	https://doi.org/10.1016/j.febslet.2012.01.048
Status	Udgivet - 23 mar. 2012
Udgivet eksternt	Ja

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10.1016/j.febslet.2012.01.048

https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.febslet.2012.01.048

Citationsformater

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title = "Adaptive diversity of innate immune receptor family short pentraxins in Murinae",

abstract = "The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we examined the evolution of short pentraxins in Murinae lineages. By molecular evolutionary analysis, CRP and SAP have been experiencing rapid diversification, driven by adaptive selection. Further, our protein modeling demonstrates that adaptively selected amino acids lie in the ligand-binding region and contact region between subunits. Our findings suggest that rapid diversification of these regions could contribute to the determinants of recognizing specificity and the interaction between subunits.",

author = "Yan Li and Robins, {Judith H} and Jianping Ye and Zhiyong Huang and Qiang Wen and Guojie Zhang",

year = "2012",

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doi = "10.1016/j.febslet.2012.01.048",

language = "English",

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T1 - Adaptive diversity of innate immune receptor family short pentraxins in Murinae

AU - Li, Yan

AU - Robins, Judith H

AU - Ye, Jianping

AU - Huang, Zhiyong

AU - Wen, Qiang

AU - Zhang, Guojie

PY - 2012/3/23

Y1 - 2012/3/23

N2 - The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we examined the evolution of short pentraxins in Murinae lineages. By molecular evolutionary analysis, CRP and SAP have been experiencing rapid diversification, driven by adaptive selection. Further, our protein modeling demonstrates that adaptively selected amino acids lie in the ligand-binding region and contact region between subunits. Our findings suggest that rapid diversification of these regions could contribute to the determinants of recognizing specificity and the interaction between subunits.

AB - The short pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP) constitute a group of innate immune receptors that trigger immune activation by detecting molecules of the microbial cell wall. Here, we examined the evolution of short pentraxins in Murinae lineages. By molecular evolutionary analysis, CRP and SAP have been experiencing rapid diversification, driven by adaptive selection. Further, our protein modeling demonstrates that adaptively selected amino acids lie in the ligand-binding region and contact region between subunits. Our findings suggest that rapid diversification of these regions could contribute to the determinants of recognizing specificity and the interaction between subunits.

U2 - 10.1016/j.febslet.2012.01.048

DO - 10.1016/j.febslet.2012.01.048

M3 - Journal article

C2 - 22306119

SN - 0014-5793

VL - 586

SP - 798

EP - 803

JO - F E B S Letters

JF - F E B S Letters

IS - 6

ER -

Adaptive diversity of innate immune receptor family short pentraxins in Murinae

Abstract

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