ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

Pauliina Kronqvist; Nobuko Kawaguchi; Reidar Albrechtsen; Xiufeng Xu; Henrik Daa Schrøder; Behzad Moghadaszadeh; Finn Cilius Nielsen; Camilla Frohlich; Eva Engvall; Ulla M Wewer

doi:10.1016/S0002-9440(10)64431-8

ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

Pauliina Kronqvist, Nobuko Kawaguchi, Reidar Albrechtsen, Xiufeng Xu, Henrik Daa Schrøder, Behzad Moghadaszadeh, Finn Cilius Nielsen, Camilla Frohlich, Eva Engvall, Ulla M Wewer

Nutritional Immunology

54 Citationer (Scopus)

Abstract

Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.

Originalsprog	Engelsk
Tidsskrift	American Journal of Pathology
Vol/bind	161
Udgave nummer	5
Sider (fra-til)	1535-40
Antal sider	6
ISSN	0002-9440
DOI	https://doi.org/10.1016/S0002-9440(10)64431-8
Status	Udgivet - 1 nov. 2002

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10.1016/S0002-9440(10)64431-8

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title = "ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice",

abstract = "Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.",

keywords = "ADAM Proteins, Animals, Humans, Inflammation, Membrane Proteins, Metalloendopeptidases, Mice, Mice, Inbred mdx, Mice, Transgenic, Muscle, Skeletal, Muscular Dystrophies, Necrosis",

author = "Pauliina Kronqvist and Nobuko Kawaguchi and Reidar Albrechtsen and Xiufeng Xu and Schr{\o}der, {Henrik Daa} and Behzad Moghadaszadeh and Nielsen, {Finn Cilius} and Camilla Frohlich and Eva Engvall and Wewer, {Ulla M}",

year = "2002",

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doi = "10.1016/S0002-9440(10)64431-8",

language = "English",

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TY - JOUR

T1 - ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

AU - Kronqvist, Pauliina

AU - Kawaguchi, Nobuko

AU - Albrechtsen, Reidar

AU - Xu, Xiufeng

AU - Schrøder, Henrik Daa

AU - Moghadaszadeh, Behzad

AU - Nielsen, Finn Cilius

AU - Frohlich, Camilla

AU - Engvall, Eva

AU - Wewer, Ulla M

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.

AB - Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.

KW - ADAM Proteins

KW - Animals

KW - Humans

KW - Inflammation

KW - Membrane Proteins

KW - Metalloendopeptidases

KW - Mice

KW - Mice, Inbred mdx

KW - Mice, Transgenic

KW - Muscle, Skeletal

KW - Muscular Dystrophies

KW - Necrosis

U2 - 10.1016/S0002-9440(10)64431-8

DO - 10.1016/S0002-9440(10)64431-8

M3 - Journal article

C2 - 12414501

SN - 0002-9440

VL - 161

SP - 1535

EP - 1540

JO - American Journal of Pathology

JF - American Journal of Pathology

IS - 5

ER -

ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice

Abstract

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