Acute effect of pure oxygen breathing on diabetic macular edema

TY - JOUR

T1 - Acute effect of pure oxygen breathing on diabetic macular edema

AU - Vinten, Carl Martin

AU - La Cour, Morten

AU - Lund-Andersen, Henrik

AU - Larsen, Michael

PY - 2013

Y1 - 2013

N2 - A small-scale pilot study of the pathophysiology of diabetic macular edema (DME) was made by assessing concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), retinal artery diameter (RAD), and retinal vein diameter (RVD) in response to 120 minutes of pure oxygen breathing. Methods. Eleven eyes of 11 patients with DME were examined at baseline and while breathing pure oxygen for 120 minutes followed by 120 minutes of breathing atmospheric air. Macular volume was determined by optical coherence tomography, retinal trunk vessel diameters by fundus photography, intraocular pressure by pulse-air tonometry, and arterial blood pressure by sphygmomanometry. Results. After initiation of pure oxygen breathing, reductions of 2.6% in RAD (p=0.04) and 11.5% reduction in RVD (p<0.001) were observed while MABP increased by 5.2 mmHg. After resumption of atmospheric air breathing, RAD and RVD rapidly returned to baseline values whereas MABP remained 2.3 mmHg higher than baseline (p=0.04). Macular volume was found to be reduced by 1.2% compared to baseline (p=0.04) at 120 minutes after cessation of pure oxygbreathing and resumption of atmospheric air breathing. Conclusions. These results indicate that the vasomotor response of the retinal arteries alone cannot explain the delayed reduction in macular volume after short course of pure oxygen breathing.

AB - A small-scale pilot study of the pathophysiology of diabetic macular edema (DME) was made by assessing concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), retinal artery diameter (RAD), and retinal vein diameter (RVD) in response to 120 minutes of pure oxygen breathing. Methods. Eleven eyes of 11 patients with DME were examined at baseline and while breathing pure oxygen for 120 minutes followed by 120 minutes of breathing atmospheric air. Macular volume was determined by optical coherence tomography, retinal trunk vessel diameters by fundus photography, intraocular pressure by pulse-air tonometry, and arterial blood pressure by sphygmomanometry. Results. After initiation of pure oxygen breathing, reductions of 2.6% in RAD (p=0.04) and 11.5% reduction in RVD (p<0.001) were observed while MABP increased by 5.2 mmHg. After resumption of atmospheric air breathing, RAD and RVD rapidly returned to baseline values whereas MABP remained 2.3 mmHg higher than baseline (p=0.04). Macular volume was found to be reduced by 1.2% compared to baseline (p=0.04) at 120 minutes after cessation of pure oxygbreathing and resumption of atmospheric air breathing. Conclusions. These results indicate that the vasomotor response of the retinal arteries alone cannot explain the delayed reduction in macular volume after short course of pure oxygen breathing.

U2 - 10.5301/ejo.5000195

DO - 10.5301/ejo.5000195

M3 - Journal article

C2 - 22890599

SN - 1120-6721

SP - 0

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

ER -