Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

TY - JOUR

T1 - Acute differential effects of milk-derived dietary proteins on postprandial lipaemia in obese non-diabetic subjects

AU - Holmer-Jensen, Jens

AU - Hartvigsen, Merete

AU - Mortensen, L.S.

AU - Astrup, Arne

AU - de Vrese, M.

AU - Holst, Jens Juul

AU - Thomsen, C.

AU - Hermansen, K.

PY - 2012/1

Y1 - 2012/1

N2 - Background/Objectives: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. Subjects/Methods: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m -2) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. Results: We observed no statistically significant (P=0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P=0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins.Conclusion:We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

AB - Background/Objectives: Postprandial lipaemia is an established risk factor for atherosclerosis. To investigate the acute effect of four milk-derived dietary proteins (alpha-lactalbumin, whey isolate, caseinoglycomacropeptide and whey hydrolysate) on postprandial lipaemia, we have conducted a randomized, acute, single-blinded clinical intervention study with crossover design. Subjects/Methods: A total of 11 obese non-diabetic subjects (age: 44-74, BMI: 30-41.4 kg m -2) were included. On 4 different days the subjects ingested a high-fat meal with the following energy distribution: 66% energy from fat (100 g of butter), 15% of energy from carbohydrate (90 g of white wheat bread) and 19% of energy from protein (45 g of pure protein). Our primary variable was plasma triglyceride measured in the 8-h postprandial period. Secondarily, retinyl palmitate, non-esterified free fatty acids, glucose, insulin, glucagon, GLP-1 and GIP, active and total grehlin and cholecystokinin were measured. Results: We observed no statistically significant (P=0.8) differences between meals on our primary variable that is, triglycerides. Whey hydrolysate was associated with a significantly (P=0.02) smaller postprandial suppression of non-esterified free fatty acids compared with the other dietary proteins.Conclusion:We did not observe significant differences in postprandial lipaemia to the four milk-derived dietary proteins. Whey hydrolysate caused less postprandial suppression of free fatty acids.

KW - Adult

KW - Aged

KW - Atherosclerosis

KW - Diabetes Mellitus

KW - Diet, High-Fat

KW - Dietary Fats

KW - Fatty Acids, Nonesterified

KW - Female

KW - Humans

KW - Hyperlipidemias

KW - Male

KW - Middle Aged

KW - Milk Proteins

KW - Obesity

KW - Postprandial Period

KW - Risk Factors

KW - Single-Blind Method

KW - Triglycerides

U2 - 10.1038/ejcn.2011.142

DO - 10.1038/ejcn.2011.142

M3 - Journal article

C2 - 21792215

SN - 0954-3007

VL - 66

SP - 32

EP - 38

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

ER -