Activated T lymphocytes disappear from circulation during endotoxemia in humans

Karen Suarez Krabbe; Helle Bruunsgaard Kemp; Jesper Qvist; Lise Fonsmark; Kirsten Møller; Christian Muff Hansen; Peter Skinhøj; Bente Klarlund Pedersen

Activated T lymphocytes disappear from circulation during endotoxemia in humans

Karen Suarez Krabbe, Helle Bruunsgaard Kemp, Jesper Qvist, Lise Fonsmark, Kirsten Møller, Christian Muff Hansen, Peter Skinhøj, Bente Klarlund Pedersen

21 Citationer (Scopus)

Abstract

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

Originalsprog	Dansk
Tidsskrift	Clinical and Vaccine Immunology
Vol/bind	9
Udgave nummer	3
Sider (fra-til)	731-735
Antal sider	5
ISSN	1556-6811
Status	Udgivet - 31 dec. 2002

Citationsformater

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title = "Activated T lymphocytes disappear from circulation during endotoxemia in humans",

abstract = "Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.",

author = "{Suarez Krabbe}, Karen and Kemp, {Helle Bruunsgaard} and Jesper Qvist and Lise Fonsmark and Kirsten M{\o}ller and Hansen, {Christian Muff} and Peter Skinh{\o}j and Pedersen, {Bente Klarlund}",

year = "2002",

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language = "Dansk",

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TY - JOUR

T1 - Activated T lymphocytes disappear from circulation during endotoxemia in humans

AU - Suarez Krabbe, Karen

AU - Kemp, Helle Bruunsgaard

AU - Qvist, Jesper

AU - Fonsmark, Lise

AU - Møller, Kirsten

AU - Hansen, Christian Muff

AU - Skinhøj, Peter

AU - Pedersen, Bente Klarlund

PY - 2002/12/31

Y1 - 2002/12/31

N2 - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

AB - Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

M3 - Tidsskriftartikel

SN - 1556-6811

VL - 9

SP - 731

EP - 735

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

IS - 3

ER -