Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

Esben Thyssen Vestergaard; Astrid Johanneson Hjelholt; Rune E Kuhre; Niels Møller; Pierre Larraufie; Fiona M Gribble; Frank Reimann; Niels Jessen; Jens Juul Holst; Jens Otto Lunde Jørgensen

doi:10.1210/jc.2018-02503

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

Esben Thyssen Vestergaard, Astrid Johanneson Hjelholt, Rune E Kuhre, Niels Møller, Pierre Larraufie, Fiona M Gribble, Frank Reimann, Niels Jessen, Jens Juul Holst, Jens Otto Lunde Jørgensen

Endocrinology and Metabolism

5 Citationer (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an incretin hormone used therapeutically in type 2 diabetes and obesity. The interplay between ambient free fatty acids (FFAs) and GLP-1 remains unclear. Acipimox suppresses adipose tissue lipolysis via activation of the PUMA-G (also known as HCA2 and GPR109a) receptor. Objective: To investigate whether lowering of serum FFA level with acipimox affects GLP-1 secretion. Design: Two randomized crossover studies were performed in human subjects. Rat intestine was perfused intra-arterially and intraluminally, and L-cells were incubated with acipimox. Participants: The participants were healthy overweight subjects and hypopituitary adult patients. Interventions: The overweight participants received acipimox 250 mg 60 minutes before an oral glucose test. The hypopituitary patients received acipimox 250 mg 12, 9, and 2 hours before and during the metabolic study day, when they were studied in the basal state and during a hyperinsulinemic euglycemic clamp.

Originalsprog	Engelsk
Tidsskrift	The Journal of clinical endocrinology and metabolism
Vol/bind	104
Udgave nummer	7
Sider (fra-til)	2581-2592
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2018-02503
Status	Udgivet - 21 mar. 2019

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1210/jc.2018-02503

jc.2018-02503.pdfForlagets udgivne version, 1,14 MB

Citationsformater

Vestergaard, E. T., Hjelholt, A. J., Kuhre, R. E., Møller, N., Larraufie, P., Gribble, F. M., Reimann, F., Jessen, N., Holst, J. J., & Jørgensen, J. O. L. (2019). Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. The Journal of clinical endocrinology and metabolism, 104(7), 2581-2592. https://doi.org/10.1210/jc.2018-02503

@article{632b936e2e574b1bbc335d5204c022a6,

title = "Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients",

abstract = "Glucagon-like peptide-1 (GLP-1) is an incretin hormone used therapeutically in type 2 diabetes and obesity. The interplay between ambient free fatty acids (FFAs) and GLP-1 remains unclear. Acipimox suppresses adipose tissue lipolysis via activation of the PUMA-G (also known as HCA2 and GPR109a) receptor. Objective: To investigate whether lowering of serum FFA level with acipimox affects GLP-1 secretion. Design: Two randomized crossover studies were performed in human subjects. Rat intestine was perfused intra-arterially and intraluminally, and L-cells were incubated with acipimox. Participants: The participants were healthy overweight subjects and hypopituitary adult patients. Interventions: The overweight participants received acipimox 250 mg 60 minutes before an oral glucose test. The hypopituitary patients received acipimox 250 mg 12, 9, and 2 hours before and during the metabolic study day, when they were studied in the basal state and during a hyperinsulinemic euglycemic clamp.",

author = "Vestergaard, {Esben Thyssen} and Hjelholt, {Astrid Johanneson} and Kuhre, {Rune E} and Niels M{\o}ller and Pierre Larraufie and Gribble, {Fiona M} and Frank Reimann and Niels Jessen and Holst, {Jens Juul} and J{\o}rgensen, {Jens Otto Lunde}",

year = "2019",

month = mar,

day = "21",

doi = "10.1210/jc.2018-02503",

language = "English",

volume = "104",

pages = "2581--2592",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

AU - Vestergaard, Esben Thyssen

AU - Hjelholt, Astrid Johanneson

AU - Kuhre, Rune E

AU - Møller, Niels

AU - Larraufie, Pierre

AU - Gribble, Fiona M

AU - Reimann, Frank

AU - Jessen, Niels

AU - Holst, Jens Juul

AU - Jørgensen, Jens Otto Lunde

PY - 2019/3/21

Y1 - 2019/3/21

N2 - Glucagon-like peptide-1 (GLP-1) is an incretin hormone used therapeutically in type 2 diabetes and obesity. The interplay between ambient free fatty acids (FFAs) and GLP-1 remains unclear. Acipimox suppresses adipose tissue lipolysis via activation of the PUMA-G (also known as HCA2 and GPR109a) receptor. Objective: To investigate whether lowering of serum FFA level with acipimox affects GLP-1 secretion. Design: Two randomized crossover studies were performed in human subjects. Rat intestine was perfused intra-arterially and intraluminally, and L-cells were incubated with acipimox. Participants: The participants were healthy overweight subjects and hypopituitary adult patients. Interventions: The overweight participants received acipimox 250 mg 60 minutes before an oral glucose test. The hypopituitary patients received acipimox 250 mg 12, 9, and 2 hours before and during the metabolic study day, when they were studied in the basal state and during a hyperinsulinemic euglycemic clamp.

AB - Glucagon-like peptide-1 (GLP-1) is an incretin hormone used therapeutically in type 2 diabetes and obesity. The interplay between ambient free fatty acids (FFAs) and GLP-1 remains unclear. Acipimox suppresses adipose tissue lipolysis via activation of the PUMA-G (also known as HCA2 and GPR109a) receptor. Objective: To investigate whether lowering of serum FFA level with acipimox affects GLP-1 secretion. Design: Two randomized crossover studies were performed in human subjects. Rat intestine was perfused intra-arterially and intraluminally, and L-cells were incubated with acipimox. Participants: The participants were healthy overweight subjects and hypopituitary adult patients. Interventions: The overweight participants received acipimox 250 mg 60 minutes before an oral glucose test. The hypopituitary patients received acipimox 250 mg 12, 9, and 2 hours before and during the metabolic study day, when they were studied in the basal state and during a hyperinsulinemic euglycemic clamp.

U2 - 10.1210/jc.2018-02503

DO - 10.1210/jc.2018-02503

M3 - Journal article

C2 - 30726969

SN - 0021-972X

VL - 104

SP - 2581

EP - 2592

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 7

ER -

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater