Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery

Jonas Jensen; Carlos Armando Villagómez Hoyos; Marie Sand Traberg; Jacob Bjerring Olesen; Borislav Gueorguiev Tomov; Ramin Moshavegh; Simon Holbek; Matthias Bo Stuart; Caroline Ewertsen; Kristoffer Lindskov Hansen; Carsten Thomsen; Michael Bachmann Nielsen; Jørgen Arendt Jensen

doi:10.1016/j.ultrasmedbio.2018.03.017

Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery

Jonas Jensen, Carlos Armando Villagómez Hoyos, Marie Sand Traberg, Jacob Bjerring Olesen, Borislav Gueorguiev Tomov, Ramin Moshavegh, Simon Holbek, Matthias Bo Stuart, Caroline Ewertsen, Kristoffer Lindskov Hansen, Carsten Thomsen, Michael Bachmann Nielsen, Jørgen Arendt Jensen

Institut for Klinisk Medicin

8 Citationer (Scopus)

Abstract

The objective of the study described here was to investigate the accuracy and precision of a plane wave 2-D vector flow imaging (VFI) method in laminar and complex blood flow conditions in the healthy carotid artery. The approach was to study (i) the accuracy for complex flow by comparing the velocity field from a computational fluid dynamics (CFD) simulation to VFI estimates obtained from the scan of an anthropomorphic flow phantom and from an in vivo scan; (ii) the accuracy for laminar unidirectional flow in vivo by comparing peak systolic velocities from VFI with magnetic resonance angiography (MRA); (iii) the precision of VFI estimation in vivo at several evaluation points in the vessels. The carotid artery at the bifurcation was scanned using both fast plane wave ultrasound and MRA in 10 healthy volunteers. The MRA geometry acquired from one of the volunteers was used to fabricate an anthropomorphic flow phantom, which was also scanned using the fast plane wave sequence. The same geometry was used in a CFD simulation to calculate the velocity field. Results indicated that similar flow patterns and vortices were estimated with CFD and VFI in the phantom for the carotid bifurcation. The root-mean-square difference between CFD and VFI was within 0.12 m/s for velocity estimates in the common carotid artery and the internal branch. The root-mean-square difference was 0.17 m/s in the external branch. For the 10 volunteers, the mean difference between VFI and MRA was -0.17 m/s for peak systolic velocities of laminar flow in vivo. The precision in vivo was calculated as the mean standard deviation (SD) of estimates aligned to the heart cycle and was highest in the center of the common carotid artery (SD = 3.6% for velocity magnitudes and 4.5° for angles) and lowest in the external branch and for vortices (SD = 10.2% for velocity magnitudes and 39° for angles). The results indicate that plane wave VFI measures flow precisely and that estimates are in good agreement with a CFD simulation and MRA.

Originalsprog	Engelsk
Tidsskrift	Ultrasound in Medicine & Biology
Vol/bind	44
Udgave nummer	8
Sider (fra-til)	1727-1741
ISSN	0301-5629
DOI	https://doi.org/10.1016/j.ultrasmedbio.2018.03.017
Status	Udgivet - aug. 2018

Adgang til dokumentet

10.1016/j.ultrasmedbio.2018.03.017

Citationsformater

Jensen, J., Hoyos, C. A. V., Traberg, M. S., Olesen, J. B., Tomov, B. G., Moshavegh, R., Holbek, S., Stuart, M. B., Ewertsen, C., Hansen, K. L., Thomsen, C., Nielsen, M. B., & Jensen, J. A. (2018). Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery. Ultrasound in Medicine & Biology, 44(8), 1727-1741. https://doi.org/10.1016/j.ultrasmedbio.2018.03.017

Jensen, J, Hoyos, CAV, Traberg, MS, Olesen, JB, Tomov, BG, Moshavegh, R, Holbek, S, Stuart, MB, Ewertsen, C , Hansen, KL, Thomsen, C, Nielsen, MB & Jensen, JA 2018, 'Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery', Ultrasound in Medicine & Biology, bind 44, nr. 8, s. 1727-1741. https://doi.org/10.1016/j.ultrasmedbio.2018.03.017

@article{580d7af0d1aa4e0ea5c733eede11404b,

title = "Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery",

abstract = "The objective of the study described here was to investigate the accuracy and precision of a plane wave 2-D vector flow imaging (VFI) method in laminar and complex blood flow conditions in the healthy carotid artery. The approach was to study (i) the accuracy for complex flow by comparing the velocity field from a computational fluid dynamics (CFD) simulation to VFI estimates obtained from the scan of an anthropomorphic flow phantom and from an in vivo scan; (ii) the accuracy for laminar unidirectional flow in vivo by comparing peak systolic velocities from VFI with magnetic resonance angiography (MRA); (iii) the precision of VFI estimation in vivo at several evaluation points in the vessels. The carotid artery at the bifurcation was scanned using both fast plane wave ultrasound and MRA in 10 healthy volunteers. The MRA geometry acquired from one of the volunteers was used to fabricate an anthropomorphic flow phantom, which was also scanned using the fast plane wave sequence. The same geometry was used in a CFD simulation to calculate the velocity field. Results indicated that similar flow patterns and vortices were estimated with CFD and VFI in the phantom for the carotid bifurcation. The root-mean-square difference between CFD and VFI was within 0.12 m/s for velocity estimates in the common carotid artery and the internal branch. The root-mean-square difference was 0.17 m/s in the external branch. For the 10 volunteers, the mean difference between VFI and MRA was -0.17 m/s for peak systolic velocities of laminar flow in vivo. The precision in vivo was calculated as the mean standard deviation (SD) of estimates aligned to the heart cycle and was highest in the center of the common carotid artery (SD = 3.6% for velocity magnitudes and 4.5° for angles) and lowest in the external branch and for vortices (SD = 10.2% for velocity magnitudes and 39° for angles). The results indicate that plane wave VFI measures flow precisely and that estimates are in good agreement with a CFD simulation and MRA.",

keywords = "Adult, Blood Flow Velocity/physiology, Carotid Arteries/diagnostic imaging, Female, Humans, Male, Middle Aged, Reference Values, Reproducibility of Results, Ultrasonography/methods",

author = "Jonas Jensen and Hoyos, {Carlos Armando Villag{\'o}mez} and Traberg, {Marie Sand} and Olesen, {Jacob Bjerring} and Tomov, {Borislav Gueorguiev} and Ramin Moshavegh and Simon Holbek and Stuart, {Matthias Bo} and Caroline Ewertsen and Hansen, {Kristoffer Lindskov} and Carsten Thomsen and Nielsen, {Michael Bachmann} and Jensen, {J{\o}rgen Arendt}",

year = "2018",

month = aug,

doi = "10.1016/j.ultrasmedbio.2018.03.017",

language = "English",

volume = "44",

pages = "1727--1741",

journal = "Ultrasound in Medicine & Biology",

issn = "0301-5629",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery

AU - Jensen, Jonas

AU - Hoyos, Carlos Armando Villagómez

AU - Traberg, Marie Sand

AU - Olesen, Jacob Bjerring

AU - Tomov, Borislav Gueorguiev

AU - Moshavegh, Ramin

AU - Holbek, Simon

AU - Stuart, Matthias Bo

AU - Ewertsen, Caroline

AU - Hansen, Kristoffer Lindskov

AU - Thomsen, Carsten

AU - Nielsen, Michael Bachmann

AU - Jensen, Jørgen Arendt

PY - 2018/8

Y1 - 2018/8

N2 - The objective of the study described here was to investigate the accuracy and precision of a plane wave 2-D vector flow imaging (VFI) method in laminar and complex blood flow conditions in the healthy carotid artery. The approach was to study (i) the accuracy for complex flow by comparing the velocity field from a computational fluid dynamics (CFD) simulation to VFI estimates obtained from the scan of an anthropomorphic flow phantom and from an in vivo scan; (ii) the accuracy for laminar unidirectional flow in vivo by comparing peak systolic velocities from VFI with magnetic resonance angiography (MRA); (iii) the precision of VFI estimation in vivo at several evaluation points in the vessels. The carotid artery at the bifurcation was scanned using both fast plane wave ultrasound and MRA in 10 healthy volunteers. The MRA geometry acquired from one of the volunteers was used to fabricate an anthropomorphic flow phantom, which was also scanned using the fast plane wave sequence. The same geometry was used in a CFD simulation to calculate the velocity field. Results indicated that similar flow patterns and vortices were estimated with CFD and VFI in the phantom for the carotid bifurcation. The root-mean-square difference between CFD and VFI was within 0.12 m/s for velocity estimates in the common carotid artery and the internal branch. The root-mean-square difference was 0.17 m/s in the external branch. For the 10 volunteers, the mean difference between VFI and MRA was -0.17 m/s for peak systolic velocities of laminar flow in vivo. The precision in vivo was calculated as the mean standard deviation (SD) of estimates aligned to the heart cycle and was highest in the center of the common carotid artery (SD = 3.6% for velocity magnitudes and 4.5° for angles) and lowest in the external branch and for vortices (SD = 10.2% for velocity magnitudes and 39° for angles). The results indicate that plane wave VFI measures flow precisely and that estimates are in good agreement with a CFD simulation and MRA.

AB - The objective of the study described here was to investigate the accuracy and precision of a plane wave 2-D vector flow imaging (VFI) method in laminar and complex blood flow conditions in the healthy carotid artery. The approach was to study (i) the accuracy for complex flow by comparing the velocity field from a computational fluid dynamics (CFD) simulation to VFI estimates obtained from the scan of an anthropomorphic flow phantom and from an in vivo scan; (ii) the accuracy for laminar unidirectional flow in vivo by comparing peak systolic velocities from VFI with magnetic resonance angiography (MRA); (iii) the precision of VFI estimation in vivo at several evaluation points in the vessels. The carotid artery at the bifurcation was scanned using both fast plane wave ultrasound and MRA in 10 healthy volunteers. The MRA geometry acquired from one of the volunteers was used to fabricate an anthropomorphic flow phantom, which was also scanned using the fast plane wave sequence. The same geometry was used in a CFD simulation to calculate the velocity field. Results indicated that similar flow patterns and vortices were estimated with CFD and VFI in the phantom for the carotid bifurcation. The root-mean-square difference between CFD and VFI was within 0.12 m/s for velocity estimates in the common carotid artery and the internal branch. The root-mean-square difference was 0.17 m/s in the external branch. For the 10 volunteers, the mean difference between VFI and MRA was -0.17 m/s for peak systolic velocities of laminar flow in vivo. The precision in vivo was calculated as the mean standard deviation (SD) of estimates aligned to the heart cycle and was highest in the center of the common carotid artery (SD = 3.6% for velocity magnitudes and 4.5° for angles) and lowest in the external branch and for vortices (SD = 10.2% for velocity magnitudes and 39° for angles). The results indicate that plane wave VFI measures flow precisely and that estimates are in good agreement with a CFD simulation and MRA.

KW - Adult

KW - Blood Flow Velocity/physiology

KW - Carotid Arteries/diagnostic imaging

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Reference Values

KW - Reproducibility of Results

KW - Ultrasonography/methods

U2 - 10.1016/j.ultrasmedbio.2018.03.017

DO - 10.1016/j.ultrasmedbio.2018.03.017

M3 - Journal article

C2 - 29735315

SN - 0301-5629

VL - 44

SP - 1727

EP - 1741

JO - Ultrasound in Medicine & Biology

JF - Ultrasound in Medicine & Biology

IS - 8

ER -

Accuracy and Precision of a Plane Wave Vector Flow Imaging Method in the Healthy Carotid Artery

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater