Acceptable Success Rate in Patients With Periprosthetic Knee Joint Infection Treated With Debridement, Antibiotics, and Implant Retention

Casper S Ottesen; Anders Troelsen; Håkon Sandholdt; Steffen Jacobsen; Henrik Husted; Kirill Gromov

doi:10.1016/j.arth.2018.09.088

Acceptable Success Rate in Patients With Periprosthetic Knee Joint Infection Treated With Debridement, Antibiotics, and Implant Retention

Casper S Ottesen, Anders Troelsen, Håkon Sandholdt, Steffen Jacobsen, Henrik Husted, Kirill Gromov

Institut for Klinisk Medicin

14 Citationer (Scopus)

Abstract

BACKGROUND: Acute periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) surgery can be treated with debridement, antibiotics, and implant retention (DAIR). However, varying results have been reported in the literature and optimal timing of the procedure is still debated. In this retrospective cohort study, we investigate (a) success rate of DAIR for treating PJI following primary TKA surgery and (b) whether time after primary surgery until DAIR and (c) type of isolated microorganism influence outcome.

METHODS: Sixty-seven patients with PJI following primary TKA surgery treated with DAIR were identified. Patients with insufficient data and patients who did not fulfill Musculoskeletal Infection Society PJI criteria were excluded, leaving 58 patients for analysis. Minimum follow-up was 2 years. A DAIR was considered a success if the patient was infection free after 2 years.

RESULTS: The overall success rate of PJI treated with DAIR was 84%. Median time until DAIR was 21 days (7-1092). Thirty-four patients (59%) were revised within 28 days, 42 patients (72%) within 42 days, while 10 patients (17%) were revised more than 90 days after primary TKA surgery. The success rates were 85%, 88%, and 60%, respectively. In the patients revised within 90 days, our success rate was 90% (43/48) regardless of the involved microorganism.

CONCLUSION: We find DAIR to be a viable and safe treatment option for PJI following primary TKA surgery, when performed early after primary surgery and with the addition of a relevant postrevision antibiotic regime.

Originalsprog	Engelsk
Tidsskrift	Journal of Arthroplasty
Vol/bind	34
Udgave nummer	2
Sider (fra-til)	365-368
ISSN	0883-5403
DOI	https://doi.org/10.1016/j.arth.2018.09.088
Status	Udgivet - feb. 2019

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10.1016/j.arth.2018.09.088

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@article{b8c418513be2474595a84de2fd76d8fa,

title = "Acceptable Success Rate in Patients With Periprosthetic Knee Joint Infection Treated With Debridement, Antibiotics, and Implant Retention",

abstract = "BACKGROUND: Acute periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) surgery can be treated with debridement, antibiotics, and implant retention (DAIR). However, varying results have been reported in the literature and optimal timing of the procedure is still debated. In this retrospective cohort study, we investigate (a) success rate of DAIR for treating PJI following primary TKA surgery and (b) whether time after primary surgery until DAIR and (c) type of isolated microorganism influence outcome.METHODS: Sixty-seven patients with PJI following primary TKA surgery treated with DAIR were identified. Patients with insufficient data and patients who did not fulfill Musculoskeletal Infection Society PJI criteria were excluded, leaving 58 patients for analysis. Minimum follow-up was 2 years. A DAIR was considered a success if the patient was infection free after 2 years.RESULTS: The overall success rate of PJI treated with DAIR was 84%. Median time until DAIR was 21 days (7-1092). Thirty-four patients (59%) were revised within 28 days, 42 patients (72%) within 42 days, while 10 patients (17%) were revised more than 90 days after primary TKA surgery. The success rates were 85%, 88%, and 60%, respectively. In the patients revised within 90 days, our success rate was 90% (43/48) regardless of the involved microorganism.CONCLUSION: We find DAIR to be a viable and safe treatment option for PJI following primary TKA surgery, when performed early after primary surgery and with the addition of a relevant postrevision antibiotic regime.",

keywords = "Aged, Anti-Bacterial Agents/therapeutic use, Arthritis, Infectious/drug therapy, Arthroplasty, Replacement, Knee/adverse effects, Debridement/statistics & numerical data, Female, Humans, Knee Joint/surgery, Knee Prosthesis/adverse effects, Male, Middle Aged, Prosthesis-Related Infections/drug therapy, Retrospective Studies, Treatment Outcome",

author = "Ottesen, {Casper S} and Anders Troelsen and H{\aa}kon Sandholdt and Steffen Jacobsen and Henrik Husted and Kirill Gromov",

year = "2019",

month = feb,

doi = "10.1016/j.arth.2018.09.088",

language = "English",

volume = "34",

pages = "365--368",

journal = "Journal of Arthroplasty",

issn = "0883-5403",

publisher = "Churchill Livingstone",

number = "2",

}

TY - JOUR

T1 - Acceptable Success Rate in Patients With Periprosthetic Knee Joint Infection Treated With Debridement, Antibiotics, and Implant Retention

AU - Ottesen, Casper S

AU - Troelsen, Anders

AU - Sandholdt, Håkon

AU - Jacobsen, Steffen

AU - Husted, Henrik

AU - Gromov, Kirill

PY - 2019/2

Y1 - 2019/2

N2 - BACKGROUND: Acute periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) surgery can be treated with debridement, antibiotics, and implant retention (DAIR). However, varying results have been reported in the literature and optimal timing of the procedure is still debated. In this retrospective cohort study, we investigate (a) success rate of DAIR for treating PJI following primary TKA surgery and (b) whether time after primary surgery until DAIR and (c) type of isolated microorganism influence outcome.METHODS: Sixty-seven patients with PJI following primary TKA surgery treated with DAIR were identified. Patients with insufficient data and patients who did not fulfill Musculoskeletal Infection Society PJI criteria were excluded, leaving 58 patients for analysis. Minimum follow-up was 2 years. A DAIR was considered a success if the patient was infection free after 2 years.RESULTS: The overall success rate of PJI treated with DAIR was 84%. Median time until DAIR was 21 days (7-1092). Thirty-four patients (59%) were revised within 28 days, 42 patients (72%) within 42 days, while 10 patients (17%) were revised more than 90 days after primary TKA surgery. The success rates were 85%, 88%, and 60%, respectively. In the patients revised within 90 days, our success rate was 90% (43/48) regardless of the involved microorganism.CONCLUSION: We find DAIR to be a viable and safe treatment option for PJI following primary TKA surgery, when performed early after primary surgery and with the addition of a relevant postrevision antibiotic regime.

AB - BACKGROUND: Acute periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) surgery can be treated with debridement, antibiotics, and implant retention (DAIR). However, varying results have been reported in the literature and optimal timing of the procedure is still debated. In this retrospective cohort study, we investigate (a) success rate of DAIR for treating PJI following primary TKA surgery and (b) whether time after primary surgery until DAIR and (c) type of isolated microorganism influence outcome.METHODS: Sixty-seven patients with PJI following primary TKA surgery treated with DAIR were identified. Patients with insufficient data and patients who did not fulfill Musculoskeletal Infection Society PJI criteria were excluded, leaving 58 patients for analysis. Minimum follow-up was 2 years. A DAIR was considered a success if the patient was infection free after 2 years.RESULTS: The overall success rate of PJI treated with DAIR was 84%. Median time until DAIR was 21 days (7-1092). Thirty-four patients (59%) were revised within 28 days, 42 patients (72%) within 42 days, while 10 patients (17%) were revised more than 90 days after primary TKA surgery. The success rates were 85%, 88%, and 60%, respectively. In the patients revised within 90 days, our success rate was 90% (43/48) regardless of the involved microorganism.CONCLUSION: We find DAIR to be a viable and safe treatment option for PJI following primary TKA surgery, when performed early after primary surgery and with the addition of a relevant postrevision antibiotic regime.

KW - Aged

KW - Anti-Bacterial Agents/therapeutic use

KW - Arthritis, Infectious/drug therapy

KW - Arthroplasty, Replacement, Knee/adverse effects

KW - Debridement/statistics & numerical data

KW - Female

KW - Humans

KW - Knee Joint/surgery

KW - Knee Prosthesis/adverse effects

KW - Male

KW - Middle Aged

KW - Prosthesis-Related Infections/drug therapy

KW - Retrospective Studies

KW - Treatment Outcome

U2 - 10.1016/j.arth.2018.09.088

DO - 10.1016/j.arth.2018.09.088

M3 - Journal article

C2 - 30401558

SN - 0883-5403

VL - 34

SP - 365

EP - 368

JO - Journal of Arthroplasty

JF - Journal of Arthroplasty

IS - 2

ER -

Acceptable Success Rate in Patients With Periprosthetic Knee Joint Infection Treated With Debridement, Antibiotics, and Implant Retention

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