A unified architecture of transcriptional regulatory elements

Robin Andersson; Albin Gustav Sandelin; Charles G. Danko

doi:10.1016/j.tig.2015.05.007

A unified architecture of transcriptional regulatory elements

Robin Andersson, Albin Gustav Sandelin, Charles G. Danko

Bioinformatik og RNA Biologi

87 Citationer (Scopus)

Abstract

Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

Originalsprog	Engelsk
Tidsskrift	Trends in Genetics
Vol/bind	31
Udgave nummer	8
Sider (fra-til)	426-433
Antal sider	8
ISSN	0168-9525
DOI	https://doi.org/10.1016/j.tig.2015.05.007
Status	Udgivet - 1 aug. 2015

Adgang til dokumentet

10.1016/j.tig.2015.05.007

http://biorxiv.org/content/early/2015/05/26/019844Licens: CC BY-NC-ND

Citationsformater

@article{d79dac54251a4fb6a3cd725e20944131,

title = "A unified architecture of transcriptional regulatory elements",

abstract = "Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.",

author = "Robin Andersson and Sandelin, {Albin Gustav} and Danko, {Charles G.}",

year = "2015",

month = aug,

day = "1",

doi = "10.1016/j.tig.2015.05.007",

language = "English",

volume = "31",

pages = "426--433",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Ltd. * Trends Journals",

number = "8",

}

TY - JOUR

T1 - A unified architecture of transcriptional regulatory elements

AU - Andersson, Robin

AU - Sandelin, Albin Gustav

AU - Danko, Charles G.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

AB - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

U2 - 10.1016/j.tig.2015.05.007

DO - 10.1016/j.tig.2015.05.007

M3 - Journal article

C2 - 26073855

SN - 0168-9525

VL - 31

SP - 426

EP - 433

JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

A unified architecture of transcriptional regulatory elements

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater