A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life

Siri Beier Jensen; Anne Marie Lynge Pedersen; Arjan Vissink; Elo Andersen; Carlton G. Brown; Andrew N. Davies; Jan Dutilh; Janet S. Fulton; Ljiljana Jankovic; Nilza N. F. Lopes; Ana L. S. Mello; Luciana V. Muniz; Carol Anne Murdoch-Kinch; Raj G. Nair; Joel J. Napeñas; Angelica Nogueira-Rodrigues; Deborah Saunders; Beth Stirling; Inger von Bültzingslöwen; Dianna S. Weikel; Linda S. Elting; Fred K. L. Spijkervet; Mike T. Brennan

doi:10.1007/s00520-010-0827-8

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life

Siri Beier Jensen, Anne Marie Lynge Pedersen, Arjan Vissink, Elo Andersen, Carlton G. Brown, Andrew N. Davies, Jan Dutilh, Janet S. Fulton, Ljiljana Jankovic, Nilza N. F. Lopes, Ana L. S. Mello, Luciana V. Muniz, Carol Anne Murdoch-Kinch, Raj G. Nair, Joel J. Napeñas, Angelica Nogueira-Rodrigues, Deborah Saunders, Beth Stirling, Inger von Bültzingslöwen, Dianna S. WeikelLinda S. Elting, Fred K. L. Spijkervet, Mike T. Brennan

241 Citationer (Scopus)

Abstract

This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article. The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy. Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy

Originalsprog	Engelsk
Tidsskrift	Supportive Care in Cancer
Vol/bind	18
Udgave nummer	8
Sider (fra-til)	1039-1060
Antal sider	22
ISSN	0941-4355
DOI	https://doi.org/10.1007/s00520-010-0827-8
Status	Udgivet - aug. 2010

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10.1007/s00520-010-0827-8

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Jensen, S. B., Pedersen, A. M. L., Vissink, A., Andersen, E., Brown, C. G., Davies, A. N., Dutilh, J., Fulton, J. S., Jankovic, L., Lopes, N. N. F., Mello, A. L. S., Muniz, L. V., Murdoch-Kinch, C. A., Nair, R. G., Napeñas, J. J., Nogueira-Rodrigues, A., Saunders, D., Stirling, B., von Bültzingslöwen, I., ... Brennan, M. T. (2010). A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life. Supportive Care in Cancer, 18(8), 1039-1060. https://doi.org/10.1007/s00520-010-0827-8

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies : Prevalence, severity and impact on quality of life. / Jensen, Siri Beier; Pedersen, Anne Marie Lynge; Vissink, Arjan et al.

I: Supportive Care in Cancer, Bind 18, Nr. 8, 08.2010, s. 1039-1060.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jensen, SB, Pedersen, AML, Vissink, A, Andersen, E, Brown, CG, Davies, AN, Dutilh, J, Fulton, JS, Jankovic, L, Lopes, NNF, Mello, ALS, Muniz, LV, Murdoch-Kinch, CA, Nair, RG, Napeñas, JJ, Nogueira-Rodrigues, A, Saunders, D, Stirling, B, von Bültzingslöwen, I, Weikel, DS, Elting, LS, Spijkervet, FKL & Brennan, MT 2010, 'A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life', Supportive Care in Cancer, bind 18, nr. 8, s. 1039-1060. https://doi.org/10.1007/s00520-010-0827-8

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title = "A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life",

abstract = "Purpose: This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. Methods: The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article. Results: The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy. Conclusions: Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.",

author = "Jensen, {Siri Beier} and Pedersen, {Anne Marie Lynge} and Arjan Vissink and Elo Andersen and Brown, {Carlton G.} and Davies, {Andrew N.} and Jan Dutilh and Fulton, {Janet S.} and Ljiljana Jankovic and Lopes, {Nilza N. F.} and Mello, {Ana L. S.} and Muniz, {Luciana V.} and Murdoch-Kinch, {Carol Anne} and Nair, {Raj G.} and Nape{\~n}as, {Joel J.} and Angelica Nogueira-Rodrigues and Deborah Saunders and Beth Stirling and {von B{\"u}ltzingsl{\"o}wen}, Inger and Weikel, {Dianna S.} and Elting, {Linda S.} and Spijkervet, {Fred K. L.} and Brennan, {Mike T.}",

note = "Paper id:: 10.1007/s00520-010-0827-8",

year = "2010",

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doi = "10.1007/s00520-010-0827-8",

language = "English",

volume = "18",

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journal = "Supportive Care in Cancer",

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TY - JOUR

T1 - A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies

T2 - Prevalence, severity and impact on quality of life

AU - Jensen, Siri Beier

AU - Pedersen, Anne Marie Lynge

AU - Vissink, Arjan

AU - Andersen, Elo

AU - Brown, Carlton G.

AU - Davies, Andrew N.

AU - Dutilh, Jan

AU - Fulton, Janet S.

AU - Jankovic, Ljiljana

AU - Lopes, Nilza N. F.

AU - Mello, Ana L. S.

AU - Muniz, Luciana V.

AU - Murdoch-Kinch, Carol Anne

AU - Nair, Raj G.

AU - Napeñas, Joel J.

AU - Nogueira-Rodrigues, Angelica

AU - Saunders, Deborah

AU - Stirling, Beth

AU - von Bültzingslöwen, Inger

AU - Weikel, Dianna S.

AU - Elting, Linda S.

AU - Spijkervet, Fred K. L.

AU - Brennan, Mike T.

N1 - Paper id:: 10.1007/s00520-010-0827-8

PY - 2010/8

Y1 - 2010/8

N2 - Purpose: This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. Methods: The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article. Results: The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy. Conclusions: Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.

AB - Purpose: This systematic review aimed to assess the literature for prevalence, severity, and impact on quality of life of salivary gland hypofunction and xerostomia induced by cancer therapies. Methods: The electronic databases of MEDLINE/PubMed and EMBASE were searched for articles published in English since the 1989 NIH Development Consensus Conference on the Oral Complications of Cancer Therapies until 2008 inclusive. Two independent reviewers extracted information regarding study design, study population, interventions, outcome measures, results and conclusions for each article. Results: The inclusion criteria were met by 184 articles covering salivary gland hypofunction and xerostomia induced by conventional, 3D conformal radiotherapy or intensity-modulated radiotherapy in head and neck cancer patients, cancer chemotherapy, total body irradiation/hematopoietic stem cell transplantation, radioactive iodine treatment, and immunotherapy. Conclusions: Salivary gland hypofunction and xerostomia are induced by radiotherapy in the head and neck region depending on the cumulative radiation dose to the gland tissue. Treatment focus should be on optimized/new approaches to further reduce the dose to the parotids, and particularly submandibular and minor salivary glands, as these glands are major contributors to moistening of oral tissues. Other cancer treatments also induce salivary gland hypofunction, although to a lesser severity, and in the case of chemotherapy and immunotherapy, the adverse effect is temporary. Fields of sparse literature included pediatric cancer populations, cancer chemotherapy, radioactive iodine treatment, total body irradiation/hematopoietic stem cell transplantation, and immunotherapy.

U2 - 10.1007/s00520-010-0827-8

DO - 10.1007/s00520-010-0827-8

M3 - Journal article

SN - 0941-4355

VL - 18

SP - 1039

EP - 1060

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 8

ER -

A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life

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