A stem cell gene expression profile of human squamous cell carcinomas

Kim B Jensen; Judith Jones; Fiona M Watt

doi:10.1016/j.canlet.2008.06.014

A stem cell gene expression profile of human squamous cell carcinomas

Kim B Jensen, Judith Jones, Fiona M Watt

45 Citationer (Scopus)

Abstract

To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

Originalsprog	Engelsk
Tidsskrift	Cancer Letters
Vol/bind	272
Udgave nummer	1
Sider (fra-til)	23-31
Antal sider	9
ISSN	0304-3835
DOI	https://doi.org/10.1016/j.canlet.2008.06.014
Status	Udgivet - 8 dec. 2008
Udgivet eksternt	Ja

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10.1016/j.canlet.2008.06.014

Citationsformater

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title = "A stem cell gene expression profile of human squamous cell carcinomas",

abstract = "To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.",

keywords = "Adaptor Proteins, Signal Transducing, Carcinoma, Squamous Cell, Cell Differentiation, Cell Division, Cell Line, Tumor, Foreskin, GTP-Binding Proteins, Gene Expression Profiling, Genetic Markers, Humans, Immunohistochemistry, Infant, Newborn, Keratinocytes, Male, Mouth Mucosa, Mouth Neoplasms, Polymerase Chain Reaction, RNA, Messenger, RNA, Neoplasm, Skin, Stem Cells",

author = "Jensen, {Kim B} and Judith Jones and Watt, {Fiona M}",

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doi = "10.1016/j.canlet.2008.06.014",

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T1 - A stem cell gene expression profile of human squamous cell carcinomas

AU - Jensen, Kim B

AU - Jones, Judith

AU - Watt, Fiona M

PY - 2008/12/8

Y1 - 2008/12/8

N2 - To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

AB - To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

KW - Adaptor Proteins, Signal Transducing

KW - Carcinoma, Squamous Cell

KW - Cell Differentiation

KW - Cell Division

KW - Cell Line, Tumor

KW - Foreskin

KW - GTP-Binding Proteins

KW - Gene Expression Profiling

KW - Genetic Markers

KW - Humans

KW - Immunohistochemistry

KW - Infant, Newborn

KW - Keratinocytes

KW - Male

KW - Mouth Mucosa

KW - Mouth Neoplasms

KW - Polymerase Chain Reaction

KW - RNA, Messenger

KW - RNA, Neoplasm

KW - Skin

KW - Stem Cells

U2 - 10.1016/j.canlet.2008.06.014

DO - 10.1016/j.canlet.2008.06.014

M3 - Journal article

C2 - 18657901

SN - 0304-3835

VL - 272

SP - 23

EP - 31

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

A stem cell gene expression profile of human squamous cell carcinomas

Abstract

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