A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

S.R. Wiegell; S. Fabricius; P.A. Philipsen; J. Heydenreich; M. Hædersdal; H.C. Wulf; I.M. Stender; B. Berne; S. Kroon; B.L. Andersen; C. Mørk; C. Sandberg; G.B.E. Jemec; M. Mogensen; K.M. Brocks

doi:10.1111/j.1365-2133.2011.10209.x

A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

S.R. Wiegell, S. Fabricius, P.A. Philipsen, J. Heydenreich, M. Hædersdal, H.C. Wulf, I.M. Stender, B. Berne, S. Kroon, B.L. Andersen, C. Mørk, C. Sandberg, G.B.E. Jemec, M. Mogensen, K.M. Brocks

Institut for Klinisk Medicin

134 Citationer (Scopus)

Abstract

Background: Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience of clinic attendance and discomfort during therapy are significant drawbacks. Daylight-mediated PDT could potentially reduce these and may serve as an alternative to conventional PDT. Objectives: To compare the efficacy of methyl aminolaevulinate (MAL)-PDT with 11/2 vs. 21/2 h of daylight exposure in a randomized multicentre study. Methods: One hundred and twenty patients with a total of 1572 thin AKs of the face and scalp were randomized to either 11/2- or 21/2-h exposure groups. After gentle lesion preparation and application of a sunscreen of sun protection factor 20, MAL was applied to the entire treatment area. Immediately after, patients left the clinic and exposed themselves to daylight according to the randomization. Daylight exposure was monitored with a wristwatch dosimeter and patients scored their pain sensation during treatment. Results: The mean lesion response rate at 3 months was 77% in the 11/2-h group and 75% in the 21/2-h group (P = 0·57). The mean duration of daylight exposure was 131 and 187 min in the two groups. The mean overall effective light dose was 9·4 J cm^-2 (range 0·2-28·3). Response rate was not associated with effective daylight dose, exposure duration, treatment centre, time of day or time of year during which the treatment was performed. Treatment was well tolerated, with a mean ± SD maximal pain score of 1·3 ± 1·5. Conclusions: Daylight-mediated MAL-PDT is an effective, convenient and nearly pain-free treatment for patients with multiple thin AKs. Daylight-mediated PDT procedures were easily performed and 2 h of daylight exposure resulted in uniformly high response rates when conducted in the period from June to October in Nordic countries.

Originalsprog	Engelsk
Tidsskrift	British Journal of Dermatology
Vol/bind	164
Udgave nummer	5
Sider (fra-til)	1083-1090
Antal sider	8
ISSN	0007-0963
DOI	https://doi.org/10.1111/j.1365-2133.2011.10209.x
Status	Udgivet - 1 maj 2011

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Citationsformater

Wiegell, S. R., Fabricius, S., Philipsen, P. A., Heydenreich, J., Hædersdal, M., Wulf, H. C., Stender, I. M., Berne, B., Kroon, S., Andersen, B. L., Mørk, C., Sandberg, C., Jemec, G. B. E., Mogensen, M., & Brocks, K. M. (2011). A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. British Journal of Dermatology, 164(5), 1083-1090. https://doi.org/10.1111/j.1365-2133.2011.10209.x

A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. / Wiegell, S.R.; Fabricius, S.; Philipsen, P.A. et al.

I: British Journal of Dermatology, Bind 164, Nr. 5, 01.05.2011, s. 1083-1090.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Wiegell, SR, Fabricius, S, Philipsen, PA, Heydenreich, J, Hædersdal, M, Wulf, HC, Stender, IM, Berne, B, Kroon, S, Andersen, BL, Mørk, C, Sandberg, C, Jemec, GBE, Mogensen, M & Brocks, KM 2011, 'A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp', British Journal of Dermatology, bind 164, nr. 5, s. 1083-1090. https://doi.org/10.1111/j.1365-2133.2011.10209.x

Wiegell SR, Fabricius S, Philipsen PA, Heydenreich J, Hædersdal M, Wulf HC et al. A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. British Journal of Dermatology. 2011 maj 1;164(5):1083-1090. doi: 10.1111/j.1365-2133.2011.10209.x

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title = "A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp",

abstract = "Background: Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience of clinic attendance and discomfort during therapy are significant drawbacks. Daylight-mediated PDT could potentially reduce these and may serve as an alternative to conventional PDT. Objectives: To compare the efficacy of methyl aminolaevulinate (MAL)-PDT with 11/2 vs. 21/2 h of daylight exposure in a randomized multicentre study. Methods: One hundred and twenty patients with a total of 1572 thin AKs of the face and scalp were randomized to either 11/2- or 21/2-h exposure groups. After gentle lesion preparation and application of a sunscreen of sun protection factor 20, MAL was applied to the entire treatment area. Immediately after, patients left the clinic and exposed themselves to daylight according to the randomization. Daylight exposure was monitored with a wristwatch dosimeter and patients scored their pain sensation during treatment. Results: The mean lesion response rate at 3 months was 77% in the 11/2-h group and 75% in the 21/2-h group (P = 0·57). The mean duration of daylight exposure was 131 and 187 min in the two groups. The mean overall effective light dose was 9·4 J cm-2 (range 0·2-28·3). Response rate was not associated with effective daylight dose, exposure duration, treatment centre, time of day or time of year during which the treatment was performed. Treatment was well tolerated, with a mean ± SD maximal pain score of 1·3 ± 1·5. Conclusions: Daylight-mediated MAL-PDT is an effective, convenient and nearly pain-free treatment for patients with multiple thin AKs. Daylight-mediated PDT procedures were easily performed and 2 h of daylight exposure resulted in uniformly high response rates when conducted in the period from June to October in Nordic countries.",

author = "S.R. Wiegell and S. Fabricius and P.A. Philipsen and J. Heydenreich and M. H{\ae}dersdal and H.C. Wulf and I.M. Stender and B. Berne and S. Kroon and B.L. Andersen and C. M{\o}rk and C. Sandberg and G.B.E. Jemec and M. Mogensen and K.M. Brocks",

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T1 - A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2 h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp

AU - Wiegell, S.R.

AU - Fabricius, S.

AU - Philipsen, P.A.

AU - Heydenreich, J.

AU - Hædersdal, M.

AU - Wulf, H.C.

AU - Stender, I.M.

AU - Berne, B.

AU - Kroon, S.

AU - Andersen, B.L.

AU - Mørk, C.

AU - Sandberg, C.

AU - Jemec, G.B.E.

AU - Mogensen, M.

AU - Brocks, K.M.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Background: Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience of clinic attendance and discomfort during therapy are significant drawbacks. Daylight-mediated PDT could potentially reduce these and may serve as an alternative to conventional PDT. Objectives: To compare the efficacy of methyl aminolaevulinate (MAL)-PDT with 11/2 vs. 21/2 h of daylight exposure in a randomized multicentre study. Methods: One hundred and twenty patients with a total of 1572 thin AKs of the face and scalp were randomized to either 11/2- or 21/2-h exposure groups. After gentle lesion preparation and application of a sunscreen of sun protection factor 20, MAL was applied to the entire treatment area. Immediately after, patients left the clinic and exposed themselves to daylight according to the randomization. Daylight exposure was monitored with a wristwatch dosimeter and patients scored their pain sensation during treatment. Results: The mean lesion response rate at 3 months was 77% in the 11/2-h group and 75% in the 21/2-h group (P = 0·57). The mean duration of daylight exposure was 131 and 187 min in the two groups. The mean overall effective light dose was 9·4 J cm-2 (range 0·2-28·3). Response rate was not associated with effective daylight dose, exposure duration, treatment centre, time of day or time of year during which the treatment was performed. Treatment was well tolerated, with a mean ± SD maximal pain score of 1·3 ± 1·5. Conclusions: Daylight-mediated MAL-PDT is an effective, convenient and nearly pain-free treatment for patients with multiple thin AKs. Daylight-mediated PDT procedures were easily performed and 2 h of daylight exposure resulted in uniformly high response rates when conducted in the period from June to October in Nordic countries.

AB - Background: Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience of clinic attendance and discomfort during therapy are significant drawbacks. Daylight-mediated PDT could potentially reduce these and may serve as an alternative to conventional PDT. Objectives: To compare the efficacy of methyl aminolaevulinate (MAL)-PDT with 11/2 vs. 21/2 h of daylight exposure in a randomized multicentre study. Methods: One hundred and twenty patients with a total of 1572 thin AKs of the face and scalp were randomized to either 11/2- or 21/2-h exposure groups. After gentle lesion preparation and application of a sunscreen of sun protection factor 20, MAL was applied to the entire treatment area. Immediately after, patients left the clinic and exposed themselves to daylight according to the randomization. Daylight exposure was monitored with a wristwatch dosimeter and patients scored their pain sensation during treatment. Results: The mean lesion response rate at 3 months was 77% in the 11/2-h group and 75% in the 21/2-h group (P = 0·57). The mean duration of daylight exposure was 131 and 187 min in the two groups. The mean overall effective light dose was 9·4 J cm-2 (range 0·2-28·3). Response rate was not associated with effective daylight dose, exposure duration, treatment centre, time of day or time of year during which the treatment was performed. Treatment was well tolerated, with a mean ± SD maximal pain score of 1·3 ± 1·5. Conclusions: Daylight-mediated MAL-PDT is an effective, convenient and nearly pain-free treatment for patients with multiple thin AKs. Daylight-mediated PDT procedures were easily performed and 2 h of daylight exposure resulted in uniformly high response rates when conducted in the period from June to October in Nordic countries.

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