A problem of persistence: still more questions than answers?

Nathalie Q. Balaban; Kenn Gerdes; Kim Lewis; John D. McKinney

doi:10.1038/nrmicro3076

A problem of persistence: still more questions than answers?

Nathalie Q. Balaban, Kenn Gerdes, Kim Lewis, John D. McKinney

161 Citationer (Scopus)

Abstract

The current antibiotic resistance crisis has led to increased pressure to prioritize strategies to tackle the issue, with a strong focus being placed on the development of novel antimicrobials. However, one major obstacle that is often overlooked is persister cells, which are refractory to antibiotic treatment. Tackling persistence is a challenge because these cell types are extremely difficult to study and, consequently, little is known about their physiology and the factors that lead to their emergence. Here, four experts contemplate the main physiological features that define persistence and the implications of persistence for antibiotic treatment regimens, and consider what the study of bacterial persistence has taught us about the heterogeneity of bacterial populations.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews. Microbiology
Vol/bind	11
Udgave nummer	8
Sider (fra-til)	587-591
Antal sider	5
ISSN	1740-1526
DOI	https://doi.org/10.1038/nrmicro3076
Status	Udgivet - aug. 2013
Udgivet eksternt	Ja

Adgang til dokumentet

10.1038/nrmicro3076

Citationsformater

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