A pilot study of muscle plasma protein changes after exercise

Julia R Dahlqvist; Line G Voss; Thomas Lauridsen; Thomas O Krag; John Vissing

doi:10.1002/mus.23909

A pilot study of muscle plasma protein changes after exercise

Julia R Dahlqvist, Line G Voss, Thomas Lauridsen, Thomas O Krag, John Vissing

Institut for Klinisk Medicin

14 Citationer (Scopus)

Abstract

INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.

METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.

RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.

CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.

Originalsprog	Engelsk
Tidsskrift	Muscle & Nerve
Vol/bind	49
Udgave nummer	2
Sider (fra-til)	261-266
Antal sider	6
ISSN	0148-639X
DOI	https://doi.org/10.1002/mus.23909
Status	Udgivet - feb. 2014

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10.1002/mus.23909

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mus.23909

Citationsformater

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title = "A pilot study of muscle plasma protein changes after exercise",

abstract = "INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.",

keywords = "Adolescent, Adult, Biological Markers, Case-Control Studies, Connectin, Creatine Kinase, Energy Metabolism, Exercise, Female, Glycogen, Glycogen Storage Disease Type V, Humans, Male, Middle Aged, Muscle Fibers, Skeletal, Muscle, Skeletal, Muscular Dystrophy, Duchenne, Pilot Projects, Sarcomeres, Troponin I, Young Adult",

author = "Dahlqvist, {Julia R} and Voss, {Line G} and Thomas Lauridsen and Krag, {Thomas O} and John Vissing",

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year = "2014",

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doi = "10.1002/mus.23909",

language = "English",

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journal = "Muscle & Nerve",

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T1 - A pilot study of muscle plasma protein changes after exercise

AU - Dahlqvist, Julia R

AU - Voss, Line G

AU - Lauridsen, Thomas

AU - Krag, Thomas O

AU - Vissing, John

PY - 2014/2

Y1 - 2014/2

N2 - INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.

AB - INTRODUCTION: Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.METHODS: Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.RESULTS: Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.CONCLUSIONS: Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.

KW - Adolescent

KW - Adult

KW - Biological Markers

KW - Case-Control Studies

KW - Connectin

KW - Creatine Kinase

KW - Energy Metabolism

KW - Exercise

KW - Female

KW - Glycogen

KW - Glycogen Storage Disease Type V

KW - Humans

KW - Male

KW - Middle Aged

KW - Muscle Fibers, Skeletal

KW - Muscle, Skeletal

KW - Muscular Dystrophy, Duchenne

KW - Pilot Projects

KW - Sarcomeres

KW - Troponin I

KW - Young Adult

U2 - 10.1002/mus.23909

DO - 10.1002/mus.23909

M3 - Journal article

C2 - 23716353

SN - 0148-639X

VL - 49

SP - 261

EP - 266

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 2

ER -

A pilot study of muscle plasma protein changes after exercise

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