A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

Juan J Rubal; F Javier Moreno-Dorado; Francisco M Guerra; Zacarías D Jorge; María del Carmen Galán; Ginés M Salido; Søren Brøgger Christensen; Helmer Søhoel; Guillermo M Massanet

doi:10.1055/s-0029-1186056

A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca⁺²-ATPase inhibitors from Thapsia villosa

Juan J Rubal, F Javier Moreno-Dorado, Francisco M Guerra, Zacarías D Jorge, María del Carmen Galán, Ginés M Salido, Søren Brøgger Christensen, Helmer Søhoel, Guillermo M Massanet

7 Citationer (Scopus)

Abstract

A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca ²⁺-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca²⁺] in human platelets in a concentration-dependent manner.

Originalsprog	Engelsk
Tidsskrift	Planta Medica
Vol/bind	76
Udgave nummer	3
Sider (fra-til)	284-290
ISSN	0032-0943
DOI	https://doi.org/10.1055/s-0029-1186056
Status	Udgivet - 2010

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1055/s-0029-1186056

Citationsformater

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title = "A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa",

abstract = "A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca 2+-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca2+] in human platelets in a concentration-dependent manner.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Rubal, {Juan J} and Moreno-Dorado, {F Javier} and Guerra, {Francisco M} and Jorge, {Zacar{\'i}as D} and Gal{\'a}n, {Mar{\'i}a del Carmen} and Salido, {Gin{\'e}s M} and Christensen, {S{\o}ren Br{\o}gger} and Helmer S{\o}hoel and Massanet, {Guillermo M}",

note = "Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors",

year = "2010",

doi = "10.1055/s-0029-1186056",

language = "English",

volume = "76",

pages = "284--290",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "GeorgThieme Verlag",

number = "3",

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TY - JOUR

T1 - A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa

AU - Rubal, Juan J

AU - Moreno-Dorado, F Javier

AU - Guerra, Francisco M

AU - Jorge, Zacarías D

AU - Galán, María del Carmen

AU - Salido, Ginés M

AU - Christensen, Søren Brøgger

AU - Søhoel, Helmer

AU - Massanet, Guillermo M

N1 - Keywords: Thapsia villosa; Apiaceae; Germacranes; Phenylpropanoids; Slovenolides; Thapsigargins; Transtaganolides; Ca+2-ATPase inhibitors

PY - 2010

Y1 - 2010

N2 - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca 2+-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca2+] in human platelets in a concentration-dependent manner.

AB - A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of Thapsia villosa var. villosa L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca 2+-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca2+] in human platelets in a concentration-dependent manner.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1055/s-0029-1186056

DO - 10.1055/s-0029-1186056

M3 - Journal article

C2 - 19708003

SN - 0032-0943

VL - 76

SP - 284

EP - 290

JO - Planta Medica

JF - Planta Medica

IS - 3